This is a 5-year renewal application to support 5 postdoctoral trainees for a broad training program in Academic Endocrinology. This program has been in place at the Brigham and Women's Hospital/Harvard Medical School since 1985 and has been highly successful in training physician-scientists and basic scientists, many of whom remain in academic endocrinology. In the last 10 year period, more than 70% of the 14 trainees who have completed their training remain in a research career. The faculty combines both the physician- scientists of the Endocrinology Division with those basic scientists of the Harvard Medical School faculty whose research is significantly related to endocrinology and who have a past and current history of collaborative interactions with Program faculty members in the Endocrinology Division. Over the last ten years, these 21 faculty members have trained over 250 postdoctoral fellows, the great majority of whom remain in research- related careers, either in academic positions or in industry. The faculty are well-funded, with estimated modified direct costs per annum of over $50 million. The 5 trainees appointed each year will be individuals with MD, PhD, or MD/PhD degrees and they will undertake 3-4 years of an intensive research experience with an emphasis on translational investigation. The goal of the program is to provide the trainees with sufficient expertise to apply successfully for mentored research awards, such as K23, K08, K01 or K99 awards, or independent research grants such as R01 grants, as indicated, to ultimately develop into translational endocrine investigators who will address the great needs for research into endocrine and metabolic disorders that are so prevalent and cause such great morbidity in our society. The areas of research interest of the faculty include regulation of energy expenditure, insulin sensitivity, the role of the iodothyronin deiodinases in controlling differentiation and cell division via local activation and inactivation f thyroid hormone, mechanisms of calcium signaling, the process of bone development and its clinical implications, neuroendocrinology, the study of G protein-coupled receptors, the control of skeletal muscle development, differentiation, and repair, and mechanisms of muscle proteolysis in cachexia and muscle atrophy, the mechanisms of steroid hormone action, and the epidemiology of diabetes, obesity, and vitamin D deficiency disorders. There is also a strong emphasis on genetics, epigenetics, and new technologies for translating science into therapeutics. Individuals in this program will be trained to translate the insights they gain to develop strategies for the treatment and prevention of common endocrinology-based public health problems, including diabetes, obesity and osteoporosis.

Public Health Relevance

This Endocrinology Training Program assembles a group of outstanding clinical and basic scientists to oversee the training of fellows with an interest in understanding the mechanism and regulation of hormone effects and how they are disrupted to produce clinical disorders. Fellows will be trained in research techniques in order to contribute to the understanding and treatment of major endocrine-related disorders, such as obesity, diabetes, and osteoporosis

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Kalliora, Charikleia; Mamoulakis, Charalampos; Vasilopoulos, Eleni et al. (2018) Association of pesticide exposure with human congenital abnormalities. Toxicol Appl Pharmacol 346:58-75
Stamatiades, George A; Ioannou, Petros; Petrikkos, George et al. (2018) Fungal infections in patients with inflammatory bowel disease: A systematic review. Mycoses 61:366-376
Stamatiades, George A; Kaiser, Ursula B (2018) Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol 463:131-141
Papaioannou, Garyfallia; Petit, Elizabeth T; Liu, Eva S et al. (2017) Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem 292:3164-3171
Hatting, Maximilian; Rines, Amy K; Luo, Chi et al. (2017) Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting. Cell Metab 25:428-437
Wu, Elizabeth Y; Lebastchi, Jasmin; Marqusee, Ellen et al. (2017) A case of primary secretory carcinoma of the thyroid with high-grade features. Histopathology 71:665-669
Roberts, Stephanie A; Moon, Jennifer E; Dauber, Andrew et al. (2017) Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. J Pediatr Endocrinol Metab 30:343-347
Liu, Xiaoyun; Medici, Marco; Kwong, Norra et al. (2016) Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis. Thyroid 26:256-61
Liu, Eva S; Raimann, Adalbert; Chae, Byongsoo Timothy et al. (2016) c-Raf promotes angiogenesis during normal growth plate maturation. Development 143:348-55
Kakarmath, Sujay; Heller, Howard T; Alexander, Caroline A et al. (2016) Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma. J Clin Endocrinol Metab 101:4938-4944

Showing the most recent 10 out of 111 publications