Abstract

This program started over 19 years ago under the leadership of Dr. Vincent Marchesi in the Department of Pathology at Yale University School of Medicine. Under the present leadership of Dr. Jon S. Morrow, the purpose of the program is to provide postdoctoral fellows (M.D. and Ph.D.) with training in biochemical, cell biological, and molecular genetic aspects of pathobiology, and predoctoral students in a combined experimental pathology and biology graduate program. There are 29 participating faculty in the program; most have primary appointments in either the Department of Pathology or Department of Biology. Both postdoctoral and predoctoral training are research intensive; in additional, students are required to attend certain core courses in the classroom and actively participate in various seminars and research presentations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007556-24
Application #
6176279
Study Section
Special Emphasis Panel (SRC)
Program Officer
Bishop, Terry Rogers
Project Start
1977-07-01
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
24
Fiscal Year
2000
Total Cost
$136,385
Indirect Cost

  Institution

Name
Yale University
Department
Pathology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Sanada, Chad; Xavier-Ferrucio, Juliana; Lu, Yi-Chien et al. (2016) Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood 128:923-33
Reza, Faisal; Glazer, Peter M (2015) Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules. Methods Mol Biol 1239:39-73
Reza, Faisal; Glazer, Peter M (2014) Triplex-mediated genome targeting and editing. Methods Mol Biol 1114:115-42
Chin, Joanna Y; Reza, Faisal; Glazer, Peter M (2013) Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Mol Ther 21:580-7
Li, Qi; Canosa, Sandra; Flynn, Kelly et al. (2013) Modeling the neurovascular niche: unbiased transcriptome analysis of the murine subventricular zone in response to hypoxic insult. PLoS One 8:e76265
Flynn, Kelly M; Michaud, Michael; Canosa, Sandra et al. (2013) CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism. Angiogenesis 16:689-705
Flynn, Kelly M; Michaud, Michael; Madri, Joseph A (2013) CD44 deficiency contributes to enhanced experimental autoimmune encephalomyelitis: a role in immune cells and vascular cells of the blood-brain barrier. Am J Pathol 182:1322-36
Cheng, Ee-Chun; Luo, Qing; Bruscia, Emanuela M et al. (2009) Role for MKL1 in megakaryocytic maturation. Blood 113:2826-34
Wu, Yue; Zhan, Lijun; Ai, Youxi et al. (2007) MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. Biochem Biophys Res Commun 358:170-5
Gratzinger, Dita; Barreuther, Mark; Madri, Joseph A (2003) Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. Biochem Biophys Res Commun 301:243-9

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