Support is requested to continue what has proved to be a highly successful program for the training of postdoctoral fellows (M.D. and Ph.D.) in biochemical, cell biological, and molecular genetic aspects of pathobiology, and predoctoral students in a combined experimental pathology (molecular medicine and pharmacology) and biology graduate program. Historically, this program has attracted fellows who have already had formal training in diagnostic pathology or related disciplines, and who have used the opportunities provided by the training program to work on basic mechanisms of disease at the molecular level. The program has also attracted Ph.D.'s to disease-related problems. Since the expansion of the program to include predoctoral trainees during the last two competitive renewals, several of these participants have also focused their training in disease related areas. Since the inception of this program, a very high percentage of trainees have gone on to establish themselves as productive independent investigators in academic and industrial positions. Many have remained in academic pathology. During the last renewal period, an expansion of the program was sought to reflect growth in the training faculty, and to better balance support between pre- and post-doctoral candidates. This decision to seek an expansion of the predoctoral training aspects of the program reflected the success enjoyed by the innovative predoctoral program initiated by the fusion of Ph.D. programs in experimental pathology (Pathology Department) and Biology under auspices of this program four years ago. This expansion was approved by the review section, but funding for it was reduced when the award was made. Since that time, we have strengthened even further our predoctoral programs with the creation of an integrated interdisciplinary graduate program at Yale in the Biological Sciences. Given the continuing and still growing demand for basic science investigators focused on disease oriented research, with a sophisticated understanding of disease processes and pathobiology, we are again seeking an expansion of the program to the levels approved last time. At the predoctoral level, this program is available to trainees enrolled in the School of Graduate Studies of either the Yale School of Medicine (YSM) or the Faculty of Arts and Sciences (FAS). Significant contributions to the program are made by faculty in Pathology, Genetics, Molecular and Cellular Biology, and others.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007556-26
Application #
6502188
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Bishop, Terry Rogers
Project Start
1977-07-01
Project End
2007-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
26
Fiscal Year
2002
Total Cost
$219,303
Indirect Cost
Name
Yale University
Department
Pathology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Sanada, Chad; Xavier-Ferrucio, Juliana; Lu, Yi-Chien et al. (2016) Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood 128:923-33
Reza, Faisal; Glazer, Peter M (2015) Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules. Methods Mol Biol 1239:39-73
Reza, Faisal; Glazer, Peter M (2014) Triplex-mediated genome targeting and editing. Methods Mol Biol 1114:115-42
Chin, Joanna Y; Reza, Faisal; Glazer, Peter M (2013) Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Mol Ther 21:580-7
Li, Qi; Canosa, Sandra; Flynn, Kelly et al. (2013) Modeling the neurovascular niche: unbiased transcriptome analysis of the murine subventricular zone in response to hypoxic insult. PLoS One 8:e76265
Flynn, Kelly M; Michaud, Michael; Canosa, Sandra et al. (2013) CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism. Angiogenesis 16:689-705
Flynn, Kelly M; Michaud, Michael; Madri, Joseph A (2013) CD44 deficiency contributes to enhanced experimental autoimmune encephalomyelitis: a role in immune cells and vascular cells of the blood-brain barrier. Am J Pathol 182:1322-36
Cheng, Ee-Chun; Luo, Qing; Bruscia, Emanuela M et al. (2009) Role for MKL1 in megakaryocytic maturation. Blood 113:2826-34
Wu, Yue; Zhan, Lijun; Ai, Youxi et al. (2007) MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. Biochem Biophys Res Commun 358:170-5
Gratzinger, Dita; Barreuther, Mark; Madri, Joseph A (2003) Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. Biochem Biophys Res Commun 301:243-9

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