This is the competing renewal application for a T32 program that has been supporting research training in the Duke GI Division since 1965. The goal of the program remains to train outstanding individuals with doctoral degrees (MD, PhD, or MD/PhD) to conduct independent investigation relevant to the basic mechanisms, treatment, and outcomes of gastrointestinal, pancreatic, and liver diseases. Since funding was last renewed in 2006, the program has graduated 4 MD researchers (2 men/2 women), all of whom are now full members of the Duke GI Division faculty. Each has already secured further research career development funding from NIH and/or foundations. Another 3 MD trainees (including an Asian American woman) will soon be completing T32 training support. All of these will also remain at Duke to continue training, and two of the three recently won research grants to support their continued career development. Another two MDs (including a woman) will enter the T32 program in July 2010. Two other MD trainees, including an African American woman, have been selected for enrollment in July 2011. During this renewal, the training program has been re-organized into 3 Tracks to more clearly delineate the training programs and faculty in our three areas of research excellence: basic science (Track I), clinical research (Track II) and outcomes research (Track III). It provides a unique opportunity for intensive training in techniques, concepts, principles, and attitudes which will permit our trainees to pursue a career in research into the basic mechanisms, treatments, and outcomes of GI/liver diseases. Physicians and Ph.D.s trained by our program will be optimally prepared to play key roles in translational research aimed at: 1) elucidating disease mechanisms using state of the art molecular approaches;2) gaining new clinical insights into the diagnosis and natural history of GI/liver diseases;3) development of new treatment approaches for GI and liver disorders;and 4) refining clinician practice and health delivery systems to optimize the positive impacts of new knowledge/treatments of GI and liver diseases. Our program's recent track record attests to its success at achieving these mile stones that are pre-requisites for advancing prevention, treatment, and cure of GI/liver diseases.

Public Health Relevance

Continued funding for this research training program is important because the program provides physicians and Ph.D. scientists with state-of-the-art research skills, as well as knowledge of the normal physiology and disease states of gastrointestinal (GI) tract and liver, that are vital for advancing the prevention, treatment, and eventual cure of GI/liver diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
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Duke University
Internal Medicine/Medicine
Schools of Medicine
United States
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Patel, Y A; Gifford, E J; Glass, L M et al. (2018) Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration. Aliment Pharmacol Ther 47:268-278
Patel, Yuval A; Imperial, Joanne C; Muir, Andrew J et al. (2017) Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum. Gastroenterology 153:621-625.e7
Garcia, Jamie; Bagwell, Jennifer; Njaine, Brian et al. (2017) Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord. Curr Biol 27:1982-1989.e3
Henson, Jacqueline B; Patel, Yuval A; King, Lindsay Y et al. (2017) Outcomes of liver retransplantation in patients with primary sclerosing cholangitis. Liver Transpl 23:769-780
Ye, Lihua; Liddle, Rodger A (2017) Gastrointestinal hormones and the gut connectome. Curr Opin Endocrinol Diabetes Obes 24:9-14
Xie, Guanhua; Swiderska-Syn, Marzena; Jewell, Mark L et al. (2017) Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. BMC Cell Biol 18:20
Henson, Jacqueline B; Patel, Yuval A; Wilder, Julius M et al. (2017) Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis. Dig Dis Sci 62:3200-3209
Patel, Vaishali A; Romain, Paul St; Sanchez, Juan et al. (2017) Obstructive Sleep Apnea Increases the Risk of Cardiopulmonary Adverse Events Associated with Ambulatory Colonoscopy Independent of Body Mass Index. Dig Dis Sci 62:2834-2839
Patel, Yuval A; Henao, Ricardo; Moylan, Cynthia A et al. (2016) Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. Am J Gastroenterol 111:1591-1598
Patel, Yuval A; Muir, Andrew J (2016) Evaluation of New-Onset Ascites. JAMA 316:340-1

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