This application requests support for an existing training grant in Endocrinology, Metabolism and Nutrition This program was revised 10 years ago to integrate NIH supported research training program in Endocrinology/Metabolism and nutrition (KD07214 and DK07461) The proposed grant will support 3 MD and/or PhD postdoctoral fellows The past and present Endocrinology and Nutrition Programs have provided research training to 119 individuals over 36 years, over 80% of them continue or participated in full-time teaching and/or research activities, most with independent peer-reviewed support Research opportunities include basic and clinical investigations in three major areas Reproductive Biology, Diabetes, Metabolism and Nutrition, and Thyroid, Immune responses, and cell signaling This multidisciplinary program is enhanced by two NIH funded Centers General Clinical Research Center (GCRC) and Clinical Nutrition Research Unit, a World Health Organization Center in Reproduction, a Mellon Foundation Reproductive Biology Center, the UCLA Olympic Laboratory, and the NIH supported City of Hope Islet Cell Resource Center Health care professionals and basic scientists will be selected on the basis of past performance, letters of recommendation and commitment to a future academic career The PhD trainees spend full-time and MD trainees spend 80% or more of their time in research All fellows participate in Core Lecture Series, seminars and conferences, and regular interactive sessions with their mentors and their collaborative research groups A formal program on Responsible Conduct of Research is provided to all trainees Graduates of this program will be able to assume roles as independent investigators The research facilities are primarily housed at the Harbor-UCLA Medical Center and include a 25,000 sq ft research building housing the Divisions of Endocrinology and Perinatology, GCRC Core Laboratory, Stable Isotope Facility, Reproductive Morphology and Molecular Biology Units, and Computer and Biostatistics Facilities Additional research space houses mentor research labs, Molecular Genetics, Molecular Medicine, Molecular Pathology, Cognitive and Structural Neurology, Molecular Urology, the GCRC Inpatient and Ambulatory Center, and Body Composition Core.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
La Biomed Research Institute/ Harbor UCLA Medical Center
United States
Zip Code
Mohler 3rd, Emile R; Ellenberg, Susan S; Lewis, Cora E et al. (2018) The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials. J Clin Endocrinol Metab 103:681-688
Ayoub, R; Page, S T; Swerdloff, R S et al. (2017) Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive. Andrology 5:278-285
Piotrowska, Katarzyna; Wang, Christina; Swerdloff, Ronald S et al. (2017) Male hormonal contraception: hope and promise. Lancet Diabetes Endocrinol 5:214-223
Khazai, Bahram; Golden, Sherita Hill; Colangelo, Laura A et al. (2016) Association of endogenous testosterone with subclinical atherosclerosis in men: the multi-ethnic study of atherosclerosis. Clin Endocrinol (Oxf) 84:700-7
Du, Juan; Leung, Amy; Trac, Candi et al. (2016) Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin 9:28
Leung, Amy; Trac, Candi; Du, Juan et al. (2016) Persistent Chromatin Modifications Induced by High Fat Diet. J Biol Chem 291:10446-55
Abd Alamir, Moshrik; Ellenberg, Susan S; Swerdloff, Ronald S et al. (2016) The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis. Coron Artery Dis 27:95-103
Leung, Amy; Stapleton, Kenneth; Natarajan, Rama (2016) Functional Long Non-coding RNAs in Vascular Smooth Muscle Cells. Curr Top Microbiol Immunol 394:127-41
Jia, Yue; Ohanyan, Aikoui; Lue, Yan-He et al. (2015) The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis 20:551-61
Swerdloff, Ronald S; Pak, Youngju; Wang, Christina et al. (2015) Serum Testosterone (T) Level Variability in T Gel-Treated Older Hypogonadal Men: Treatment Monitoring Implications. J Clin Endocrinol Metab 100:3280-7

Showing the most recent 10 out of 52 publications