Abstract

This is a competitive year 16 renewal to request funding allowing us to continue a highly successful interdisciplinary training program in cellular and molecular endocrinology at the Mount Sinai School of Medicine in New York. Training will take place entirely within the Mount Sinai campus and will be combined with a detailed series of didactic courses, seminars, and laboratory interactions. Experienced basic science and clinical faculty with expertise in the endocrine sciences, combined with the historical contributions of Mount Sinai scientists to endocrinology, makes this an excellent environment for training. We, therefore, request increased support for 4 pre-doctoral and 5 post-doctoral trainees who will be assigned to an experienced group of preceptors to provide training and research in fundamental cellular and molecular biological techniques in a wide choice of endocrine systems

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007645-20
Application #
7677504
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1989-12-01
Project End
2011-08-31
Budget Start
2009-09-01
Budget End
2011-08-31
Support Year
20
Fiscal Year
2009
Total Cost
$91,191
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Sadahiro, Masato; Erickson, Connor; Lin, Wei-Jye et al. (2015) Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of ""humanized"" knockin mice expressing full-length or truncated VGF. Endocrinology 156:1724-38
Fargali, Samira; Garcia, Angelo L; Sadahiro, Masato et al. (2014) The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J 28:2120-33
Rangamani, Padmini; Lipshtat, Azi; Azeloglu, Evren U et al. (2013) Decoding information in cell shape. Cell 154:1356-69
Fargali, Samira; Scherer, Thomas; Shin, Andrew C et al. (2012) Germline ablation of VGF increases lipolysis in white adipose tissue. J Endocrinol 215:313-22
Rangamani, Padmini; Fardin, Marc-Antoine; Xiong, Yuguang et al. (2011) Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophys J 100:845-57
Xiong, Yuguang; Rangamani, Padmini; Fardin, Marc-Antoine et al. (2010) Mechanisms controlling cell size and shape during isotropic cell spreading. Biophys J 98:2136-46
Ma, Risheng; Latif, Rauf; Davies, Terry F (2009) Thyrotropin-independent induction of thyroid endoderm from embryonic stem cells by activin A. Endocrinology 150:1970-5
Watson, Elizabeth; Fargali, Samira; Okamoto, Haruka et al. (2009) Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure. BMC Physiol 9:19
Ren, Min; Santhanam, Arti; Lee, Paul et al. (2007) Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37. Eukaryot Cell 6:1363-72
Watson, Elizabeth; Hahm, Seung; Mizuno, Tooru M et al. (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146:5151-63

Showing the most recent 10 out of 34 publications