We are requesting continued funding of our T32 training grant DK007647 Graduate Training in Nutrition to support for our predoctoral training program in Nutritional and Metabolic Biology. The overall goal of our program is to train individuals to become leading investigators in the field of nutritional sciences who will contribut substantially to modern biomedical research. The program consists of a highly structured didactic component and a mentored research component. Support from this grant was the key ingredient that allowed this training program in nutrition to grow from 6 PhD students and 11 faculty in 1989 to its present steady-state size of ~30 PhD students and 31 faculty. For the previous grant period, we received support for 6 Ph.D. students per year (plus supplemental support for two underrepresented minority students). Because of the growth and achievements of our training program, we are requesting support for 7 PhD students per year in this renewal application. This training program is broadly focused on the nutritional and metabolic sciences. The required didactic training consists of graduate level basic science and nutrition courses and all PhD students participate in the Doctoral Seminar and Reviews in Nutrition course throughout their residence in the training program. All the training faculty have laboratory-based basic science research programs focused on nutrients or nutrition- related diseases such as diabetes, obesity, or cardiovascular disease. Although training focused on basic nutritional research, the program also provides a broad education in clinical and public health nutrition. The initial stages of the program provide comprehensive, structured training in modern biomedical research with a focus on nutrition and nutrition-related questions. Next, trainees are provided with rigorous mentored research training. This research training takes place in the research groups of one of the productive and well- funded independent scientists who comprise the training faculty. The data and narrative provided within this application demonstrate that we are very successfully training individuals committed to careers in research, teaching, and related professions with the fundamental knowledge, skills, and experience that are needed for developing successful, independent nutritional sciences research careers in the 21st Century.

Public Health Relevance

The discipline of nutrition touches on individuals of all nationalities and backgrounds, and indeed the most serious sequela of malnutrition are observed in the poorest and most under- represented sectors of society. In recognition of this fact, the IHN and this Training Program have long believed it was our responsibility not only to advance understanding of the underlying causes and consequences of malnutrition, both under-nutrition and increasingly, over-nutrition, but also to provide training to individuals from the communities most affected by the adverse health effects of poor nutrition. In this light, the IHN has for over 25 years maintained a vigorous PhD Training Program in nutritional sciences, renewal of support for which is sought in this application.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007647-30
Application #
9747867
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1990-09-15
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
30
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Genetics
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Chang, Chuchun L; Garcia-Arcos, Itsaso; Nyrén, Rakel et al. (2018) Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels. Arterioscler Thromb Vasc Biol 38:509-519
Chua, Chee Wai; Epsi, Nusrat J; Leung, Eva Y et al. (2018) Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. Elife 7:
Tamucci, Kirstin A; Namwanje, Maria; Fan, Lihong et al. (2018) The dark side of browning. Protein Cell 9:152-163
Ravussin, Yann; Edwin, Ethan; Gallop, Molly et al. (2018) Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding. Cell Metab 28:289-299.e5
Manterola, Marcia; Brown, Taylor M; Oh, Min Young et al. (2018) BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis. PLoS Genet 14:e1007209
Lee, Samuel X; Heine, Markus; Schlein, Christian et al. (2018) FoxO transcription factors are required for hepatic HDL cholesterol clearance. J Clin Invest 128:1615-1626
Kiryluk, Krzysztof; Bomback, Andrew S; Cheng, Yim-Ling et al. (2018) Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. Semin Nephrol 38:40-51
Do, Catherine; Shearer, Alyssa; Suzuki, Masako et al. (2017) Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era. Genome Biol 18:120
Pera, Marta; Larrea, Delfina; Guardia-Laguarta, Cristina et al. (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J 36:3356-3371
Xu, Katherine; Rosenstiel, Paul; Paragas, Neal et al. (2017) Unique Transcriptional Programs Identify Subtypes of AKI. J Am Soc Nephrol 28:1729-1740

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