This proposal is a request for continuing support of a research-based training program in Endocrinology and Metabolism at Oregon Health & Science University. The main goal of this program, now in its 10th year, is to prepare qualified trainees for successful scientific careers as independent investigators by providing intensive training in hypothesis-driven, basic and disease-oriented research in a stimulating ant collegial environment. Potential candidates will hold an MD, MD/PhD, or PhD degree. In most cases (i.e. MD and MD/PhD candidates), research training will be preceded by one year of concentrated training in clinical endocrinology and metabolism, and by formal activities designed to teach the scientific basis of endocrinology. The initial clinical year of training will be funded through institutional resources. The subsequent two years will be devoted to first hand experience and training in hypothesis-driven endocrine research under the supervision of an established investigator and will be funded by this grant. Research activities will be supplemented by weekly journal clubs, research-in-progress meetings, endocrine grand rounds, and endocrine clinical case conferences, and by formal graduate level course work tailored to the individual scientific needs of each trainee. The special strengths of this program include: 1) The diverse skills and interests of the faculty with broad strength in the areas of growth factors, thyroid, pituitary, adrenal, signal transduction, molecular genetics, diabetes, obesity, bone and mineral metabolism, lipid disorders, and reproductive endocrinology. 2) The substantial laboratory resources of the faculty and availability of a General Clinical Research Center, which facilitates training in state-of-the-art clinical investigation. 3) The outstanding environment for research in both clinical as well as cellular and molecular endocrinology and related areas at OHSU and its affiliated institutions (Vollum Institute and Oregon National Primate Research Center). A major premise of the training program is that the need for skilled physician-investigators will only continue to increase over the coming decades. This program seeks to train independent academic endocrinologists who will function as independent laboratory scientists capable of developing research programs that address endocrine disorders in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007674-13
Application #
7090629
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
1999-07-01
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
13
Fiscal Year
2006
Total Cost
$265,698
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Schwartz, Janice B; Gallagher, J Christopher; Jorde, Rolf et al. (2018) Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab 103:3278-3288
Swanson, C; Shea, S A; Wolfe, P et al. (2017) 24-hour profile of serum sclerostin and its association with bone biomarkers in men. Osteoporos Int 28:3205-3213
Swanson, Christine M; Shea, Steven A; Wolfe, Pamela et al. (2017) Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans. J Clin Endocrinol Metab 102:3722-3730
Nielson, Carrie M; Jones, Kerry S; Chun, Rene F et al. (2016) Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations. J Clin Endocrinol Metab 101:2226-34
Swanson, Christine M; Shea, Steven A; Stone, Katie L et al. (2015) Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep. J Bone Miner Res 30:199-211
Swanson, Christine M; Srikanth, Priya; Lee, Christine G et al. (2015) Associations of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D With Bone Mineral Density, Bone Mineral Density Change, and Incident Nonvertebral Fracture. J Bone Miner Res 30:1403-13
Castle, Jessica R; El Youssef, Joseph; Bakhtiani, Parkash A et al. (2015) Effect of Repeated Glucagon Doses on Hepatic Glycogen in Type 1 Diabetes: Implications for a Bihormonal Closed-Loop System. Diabetes Care 38:2115-9
Connelly, Kara J; Larson, Emily A; Marks, Daniel L et al. (2015) Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice. Endocrinology 156:193-202
Swanson, Christine M; Nielson, Carrie M; Shrestha, Smriti et al. (2014) Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH)2D3. J Clin Endocrinol Metab 99:2736-44
Caputo, Nicholas; Jackson, Melanie A; Castle, Jessica R et al. (2014) Biochemical stabilization of glucagon at alkaline pH. Diabetes Technol Ther 16:747-58

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