. This training grant in developmental endocrinology and metabolism at Children's Hospital Boston intends to provide funding for postdoctoral fellows to engage in research training leading to independent careers in academic pediatric endocrinology. Trainees enter the program with either the MD, MD/PhD or occasionally the PhD degree, and are selected from highly qualified pediatric endocrinology fellows at Children's Hospital. Areas of training include basic investigations in neuroendocrinology, calcium metabolism, carbohydrate pathophysiology, immunoendocrinology, genomic research, thyroid diseases, and bioinformatics, as well as clinical research in obesity, reproductive endocrinology, and carbohydrate metabolism. Training consists of didactic courses, including in quantitative methods and the ethical conduct of research, and an intensive period of individually mentored research. The intended average duration of training is two years. Of the 17 trainees during the past 10 years who have completed this training program, all but 1 are faculty in academic pediatric institutions (1 Associate Professor, 7 Assistant Professors, 8 Instructors). Of these, 7 have had independent NIH K awards, and 1 has an R01. Their record of publication is strong. This program takes advantage of the breadth of scientific expertise of the training faculty within the Division of Endocrinology, as well as in the larger Children's Hospital Boston community and surrounding Harvard environment. The 21 trainers include 9 pediatric endocrine physician-scientists (including 4 MD/PhDs), 9 physician-scientists of other disciplines, and 3 PhD scientists. Children's Hospital is the major training site, along with laboratories at Brigham and Women's Hospital, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, and Joslin Diabetes Center. Relevance. There is a great shortage of qualified pediatrician-scientists in the United States today, at a time when the potential for scientific breakthroughs in the treatment of pediatric diseases like obesity and diabetes is great. These diseases are a great threat to the future health of our nation's children. We hope that our program addresses this need by inspiring the early careers of a highly motivated group of pediatric endocrinology trainees immersed in a rigorous and stimulating learning environment.
| Majzoub, Joseph A; Topor, Lisa Swartz (2018) A New Model for Adrenarche: Inhibition of 3?-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. Horm Res Paediatr 89:311-319 |
| James-Todd, Tamarra; March, Melissa I; Seiglie, Jacqueline et al. (2018) Racial differences in neonatal hypoglycemia among very early preterm births. J Perinatol 38:258-263 |
| Cherella, Christine E; Breault, David T; Thaker, Vidhu et al. (2018) Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab 103:3585-3588 |
| Cherella, Christine E; Feldman, Henry A; Hollowell, Monica et al. (2018) Natural History and Outcomes of Cytologically Benign Thyroid Nodules in Children. J Clin Endocrinol Metab 103:3557-3565 |
| Toce, Michael S; Stefater, Margaret A; Breault, David T et al. (2018) A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila) 56:74-76 |
| Roberts, Stephanie A; Moon, Jennifer E; Dauber, Andrew et al. (2017) Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. J Pediatr Endocrinol Metab 30:343-347 |
| Jagannath, Vanitha A; Thaker, Vidhu; Chang, Anne B et al. (2017) Vitamin K supplementation for cystic fibrosis. Cochrane Database Syst Rev 8:CD008482 |
| Swartz, Jonathan M; Ciarlo, Ryan; Guo, Michael H et al. (2017) Two Unrelated Undervirilized 46,XY Males with Inherited NR5A1 Variants Identified by Whole-Exome Sequencing. Horm Res Paediatr 87:264-270 |
| Shirakawa, Jun; Fernandez, Megan; Takatani, Tomozumi et al. (2017) Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ? Cell Proliferation. Cell Metab 25:868-882.e5 |
| Krapivinsky, Grigory; Krapivinsky, Luba; Renthal, Nora E et al. (2017) Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A 114:E7092-E7100 |
Showing the most recent 10 out of 62 publications
