This training grant in developmental endocrinology and metabolism at Boston Children's Hospital intends to provide funding for 4 postdoctoral fellows per year to engage in research training leading to independent careers in academic pediatric endocrinology. Trainees enter the program with either the MD, MD/PhD or occasionally the PhD degree, and are selected from highly qualified pediatric endocrinology fellows at Children's Hospital. The 31 trainers include 15 pediatric endocrine physician-scientists (including 12 MD/PhDs), 12 physician-scientists of other disciplines, and 4 PhD scientists. Children's Hospital is the major training site, along with laboratories at Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Joslin Diabetes Center. The major areas of research emphasis in this training grant include clinical, translational and basic laboratory research in diabetes mellitus, obesity, neuroendocrinology, bone health, endocrine disruptors, stem cell biology, bioinformatics, and ion transport. Training consists of didactic courses, including in quantitative methods and the ethical conduct of research, and an intensive period of individually mentored research. The intended average duration of training is two years. Of the 29 trainees during the past 15 years who have completed training on this T32 grant, all but 2 are faculty in academic pediatric institutions (1 Professor, 15 Assistant Professors), 2 are in industry, and one is at the FDA. Of these, 9 have had independent NIH K awards, and 2 have one or more R01s. Their record of publication is strong. This program takes advantage of the breadth of scientific expertise of the training faculty within the Division of Endocrinology, as well as in the larger Boston Children's Hospital community and surrounding Harvard environment. Relevance. There is a great shortage of qualified pediatrician-scientists, including pediatric endocrinologists, in the United States today, at a time when the potential for scientific breakthroughs in the treatment of pediatric diseases like obesity and diabetes is great. These diseases are a great threat to the future health of our nation's children. We hope that our program addresses this need by inspiring the early careers of a highly motivated group of pediatric endocrinology trainees immersed in a rigorous and stimulating learning environment.

Public Health Relevance

attachment) This application aims to foster the training of a diverse and exceptionally well-trained group of postdoctoral fellows entering the field of pediatric endocrinology research through a training grant program at Boston Children's Hospital. To meet the growing biomedical research needs for pediatric endocrinology, each year we will provide training and support for 4 postdoctoral trainees for up to 2 years in this pediatric endocrinology training program. Based upon the extensive research programs of our faculty, and our record of successful career development of pediatric endocrinologists becoming independent researchers, we aim to support the training of a new group of pediatric endocrinology trainees who will become future leaders of academic pediatric research programs in the United States.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston Children's Hospital
United States
Zip Code
Majzoub, Joseph A; Topor, Lisa Swartz (2018) A New Model for Adrenarche: Inhibition of 3?-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. Horm Res Paediatr 89:311-319
James-Todd, Tamarra; March, Melissa I; Seiglie, Jacqueline et al. (2018) Racial differences in neonatal hypoglycemia among very early preterm births. J Perinatol 38:258-263
Cherella, Christine E; Breault, David T; Thaker, Vidhu et al. (2018) Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab 103:3585-3588
Cherella, Christine E; Feldman, Henry A; Hollowell, Monica et al. (2018) Natural History and Outcomes of Cytologically Benign Thyroid Nodules in Children. J Clin Endocrinol Metab 103:3557-3565
Toce, Michael S; Stefater, Margaret A; Breault, David T et al. (2018) A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila) 56:74-76
Swartz, Jonathan M; Ciarlo, Ryan; Guo, Michael H et al. (2017) Two Unrelated Undervirilized 46,XY Males with Inherited NR5A1 Variants Identified by Whole-Exome Sequencing. Horm Res Paediatr 87:264-270
Shirakawa, Jun; Fernandez, Megan; Takatani, Tomozumi et al. (2017) Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ? Cell Proliferation. Cell Metab 25:868-882.e5
Krapivinsky, Grigory; Krapivinsky, Luba; Renthal, Nora E et al. (2017) Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A 114:E7092-E7100
Wassner, Ari J; Della Vecchia, Margaret; Jarolim, Petr et al. (2017) Prevalence and Significance of Thyroglobulin Antibodies in Pediatric Thyroid Cancer. J Clin Endocrinol Metab 102:3146-3153
Swartz, Jonathan M; Ciarlo, Ryan; Guo, Michael H et al. (2017) A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant. Horm Res Paediatr 87:191-195

Showing the most recent 10 out of 62 publications