This competing continuation application seeks to extend the T32 DK07726 for an additional 5 years of funding and to maintain the number of trainees at 5/year (levels 5,5,6,6,7). This program, Research Training in Pediatric Nephrology, has provided the foundation for our training program for academic investigators in the area of pediatric nephrology. The goal of the Children's Hospital Boston, Division of Nephrology's fellowship and research training program is to develop academic physicians and scientists who will establish independent investigative careers in areas relevant to the understanding of childhood kidney diseases. Changes in the program in this cycle of funding include: 1) a change in Program Director, 2) an expansion in the training of Pediatric Nephrology research trainees, and 3) an increase in opportunities for the development of translational research. Dr Briscoe, who transitioned to Co-Director of the program in the previous funding period, will serve as Director of the training program in this renewal. Dr Briscoe is dedicated to the training of physician-scientists, and under his direction in this current period of funding, the program has significantly expanded. In AY2004 we had 7 Pediatric Nephrology and 23 post-doctoral research fellows in training. Currently, we have 12 Pediatric Nephrology and 25 post-doctoral research fellows. These additional trainees include Pediatric Nephrology fellows who were competitive, and were accepted into the elite national Pediatric Scientist Development Program, as well as the local Clinical investigator Training Program of the Massachusetts Institute of Technology, while training with our Program Faculty. Over the past 10 years, 36 Pediatric Nephrology trainees and 70 post-doctoral research trainees entered our program. These trainees received 90 research grants and 105 trainee awards. In addition, these 106 trainees contributed to a total of 1014 publications. Of these, 333 publications over the past 10 years were from the 36 Pediatric Nephrology trainees. Our Training Faculty are leaders in their fields, have significant experience in mentorship, and their research interests represent the diversity of disciplines within nephrology, including developmental biology, stem cell biology, genetics, renal physiology, transporter biology, glomerular disease, tubular disease, immunology, basic and translational transplantation immunobiology and vascular biology. Recently, Harvard Medical School has recognized the need for formalization of Translational Research training, and we expect that this will expand substantially during the next funding cycle as new programs and opportunities are expanding in the local area. Collectively, we have the opportunity to offer trainees access to a wide variety of research opportunities for productive research in childhood renal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007726-27S1
Application #
8112995
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J2))
Program Officer
Rankin, Tracy L
Project Start
1994-09-01
Project End
2014-06-30
Budget Start
2010-09-01
Budget End
2011-06-30
Support Year
27
Fiscal Year
2010
Total Cost
$61,895
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Jobst-Schwan, Tilman; Schmidt, Johanna Magdalena; Schneider, Ronen et al. (2018) Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model. PLoS One 13:e0191503
van der Ven, Amelie T; Connaughton, Dervla M; Ityel, Hadas et al. (2018) Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract. J Am Soc Nephrol 29:2348-2361
Daga, Ankana; Majmundar, Amar J; Braun, Daniela A et al. (2018) Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis. Kidney Int 93:204-213
Braun, Daniela A; Shril, Shirlee; Sinha, Aditi et al. (2018) Mutations in WDR4 as a new cause of Galloway-Mowat syndrome. Am J Med Genet A 176:2460-2465
van der Ven, Amelie T; Kobbe, Birgit; Kohl, Stefan et al. (2018) A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux. PLoS One 13:e0191224
Warejko, Jillian K; Schueler, Markus; Vivante, Asaf et al. (2018) Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ?43% of 35 Families With Midaortic Syndrome. Hypertension 71:691-699
Braun, Daniela A; Warejko, Jillian K; Ashraf, Shazia et al. (2018) Genetic variants in the LAMA5 gene in pediatric nephrotic syndrome. Nephrol Dial Transplant :
Boneschansker, Leo; Jorgensen, Julianne; Ellett, Felix et al. (2018) Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes. Sci Rep 8:1887
Warejko, Jillian K; Tan, Weizhen; Daga, Ankana et al. (2018) Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome. Clin J Am Soc Nephrol 13:53-62
Tan, Weizhen; Lovric, Svjetlana; Ashraf, Shazia et al. (2018) Analysis of 24 genes reveals a monogenic cause in 11.1% of cases with steroid-resistant nephrotic syndrome at a single center. Pediatr Nephrol 33:305-314

Showing the most recent 10 out of 66 publications