This application requests continued funding for an innovative and highly successful T32 training program in Pediatric Gastroenterology, Hepatology and Nutrition (GI) at Cincinnati Children's Hospital Medical Center. The training program, funded by the NIH for 25 years, has consistently produced much-needed academic pediatric gastroenterologists.
The Aims of our Program are: (1) To attract, recruit, and retain the highest quality fellows into our Program (2) To offer state of the art training to prepare fellows for an academic research career (3) To train physician scientists who will become leaders in academic medical centers Through a combination of supervised research, graduate level coursework, and dedicated mentorship provided by a consortium of primary research mentors and scholarship oversight committees, six postdoctoral trainees have a unique opportunity to develop outstanding skills and leadership over a training period of two years. We have chosen to offer this training across four key targeted areas and diseases which are aligned with the focus groups of our P30 NIDDK-supported Digestive Health Center (DDRCC) including: 1) Liver Disease and Modeling; 2) Digestive Disease and Immunity; 3) Digestive Disease and Obesity; and 4) Translational Embryology. Research training is pursued on either the Clinical or Basic/Translational Research Tracks. Outcomes, health services, or epidemiologic research projects are completed on the Clinical Research track, and include a formal program of study leading to either a Master of Science degree, or Certificate, in Clinical and Translational research. Laboratory-based research projects are completed on the Basic/Translational Research track, and include a formal program of study leading to a Certificate in Clinical and Translational Research. Each of these didactic programs provides instruction in ethics in research, study design, and statistical analysis to provide training in rigor and reproducibility of the research projects. The depth and quality of the research training is monitored by an interdisciplinary team of outstanding scientists with strong training and mentoring track records. The long-term goal of the program remains to foster the development of outstanding physician- investigators and leaders who will meet the tremendously underserved academic workforce needs in Pediatric GI.

Public Health Relevance

There is a critical shortage of investigators in pediatric gastroenterology who can advance new knowledge to improve the outcomes for children with digestive diseases. Our training program focuses on: 1) Liver Disease and Modeling, 2) Digestive Disease and Immunity, 3) Digestive Disease and Obesity, and 4) Translation Embryology. We will provide mentored training to pediatricians who will become the next generation of investigators and academic leaders in pediatric gastroenterology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007727-26
Application #
9933686
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Densmore, Christine L
Project Start
1995-01-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Wright, Sandra S; Trauernicht, Anna; Bonkowski, Erin et al. (2018) Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr 66:767-772
Taylor, Amy E; Carey, Alexandra N; Kudira, Ramesh et al. (2018) Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis. Hepatology 68:1905-1921
Kelly, Daniel; Kotliar, Michael; Woo, Vivienne et al. (2018) Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI Insight 3:
Ferguson, Anna E; Xanthakos, Stavra A; Siegel, Robert M (2018) Challenges in Screening for Pediatric Nonalcoholic Fatty Liver Disease. Clin Pediatr (Phila) 57:558-562
Galloway, David; Mezoff, Ethan; Zhang, Wujuan et al. (2018) Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. JPEN J Parenter Enteral Nutr :
Peters, Anna L (2017) 50 Years Ago in The Journal of Pediatrics: The Diagnosis of Complete Extrahepatic Obstruction by Rose Bengal I131. J Pediatr 180:162
Miloh, Tamir; Barton, Andrea; Wheeler, Justin et al. (2017) Immunosuppression in pediatric liver transplant recipients: Unique aspects. Liver Transpl 23:244-256
Mezoff, Ethan A; Lin, Tom K; Kaul, Ajay et al. (2017) A Procedural and Educational Experience Following Creation of an Advanced Pediatric Endoscopy Service. J Pediatr Gastroenterol Nutr 64:e96-e99
Ryan, Thomas D; Absalon, Michael J; de Alarcon, Alessandro et al. (2017) Airway plaque presenting after alteration of immunosuppression in a pediatric patient remote from heart transplantation. Pediatr Transplant 21:
Carey, Alexandra N; Zhang, Wujuan; Setchell, Kenneth D R et al. (2017) Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates. Pediatr Res 82:122-132

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