Nephrology Training Grant The purpose of the Duke Training Grant in Nephrology is to provide intensive research training for postdoctoral fellows focusing on areas that relate to normal kidney physiology, the pathogenesis of kidney diseases and hypertension. The primary goal of the program is to produce academic physicians as well as basic, translational and clinical scientists with investigative expertise in nephrology and hypertension. The program provides diverse opportunities for training in both basic and clinical research which in turn, permits trainees to develop the skills and flexibility necessary to respond to research demands in nephrology over the coming years. Our faculty have a wide range of interests and expertise in an array of disciplines providing integrated training in physiology, molecular and cellular biology, biochemistry, and technologies relating to genetically modified mice. For trainees interested in clinical research, ongoing programs in biometrics, decision analysis, human genetics and metabolomics provide a basis for rigorous evaluation of clinical issues related to hypertension and diseases of the kidney. We believe that the acquisition of research skills required to become a successful physician scientist is best accomplished by two to three years of intensive laboratory experience working closely with a quality preceptor. The research program is, therefore, structured to maximize time in the laboratory under the supervision of a mentor. For trainees with M.D. degrees, the program is designed to provide one year of clinical training followed by at least two years of research training that will be supporte by funds requested in this application. Formal course work, research seminars, and journal clubs supplement this laboratory experience. We anticipate that the levels of experience for trainees participating in the program will encompass fellows with minimal research experience to fellows with advanced research training including fellows with Ph.D. degrees. We are requesting funds to support three postdoctoral positions per year for fellows who will undertake at least two years of concurrent research training. Completion of this program should allow trainees to pursue careers in academic medicine with the skills to conduct high-quality research in clinical, translational and basic aspects of nephrology.

Public Health Relevance

Nephrology Training Grant Kidney diseases and hypertension are significant public health problems causing significant human suffering and consuming a substantial portion of our nation's health care resources. The purpose of the Duke Training Grant in Nephrology is to provide intensive research training for postdoctoral fellows in areas that relate to normal kidney physiology, the pathogenesis of kidney diseases and hypertension. The long-term goal of the training program is to produce physician scientists with the expertise to develop new and effective diagnostic strategies and therapies for patients with hypertension and kidney diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Olivo, Robert E; Davenport, Clemontina A; Diamantidis, Clarissa J et al. (2018) Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study. Nephrol Dial Transplant 33:992-1001
Hall, Gentzon; Lane, Brandon; Chryst-Ladd, Megan et al. (2017) Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation. Sci Rep 7:39933
Crowley, Matthew J; Diamantidis, Clarissa J; McDuffie, Jennifer R et al. (2017) Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. Ann Intern Med 166:191-200
Roberts, John K; Rao, Sunil V; Shaw, Linda K et al. (2017) Comparative Efficacy of Coronary Revascularization Procedures for Multivessel Coronary Artery Disease in Patients With Chronic Kidney Disease. Am J Cardiol 119:1344-1351
Makar, Melissa S; Pun, Patrick H (2017) Sudden Cardiac Death Among Hemodialysis Patients. Am J Kidney Dis 69:684-695
Olivo, Robert E; Scialla, Julia J (2017) Getting Out of the Phosphate Bind: Trials to Guide Treatment Targets. Clin J Am Soc Nephrol 12:868-870
Crowley, Steven D; Rudemiller, Nathan P (2017) Immunologic Effects of the Renin-Angiotensin System. J Am Soc Nephrol 28:1350-1361
Rudemiller, Nathan P; Patel, Mehul B; Zhang, Jian-Dong et al. (2016) C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. Am J Pathol 186:2846-2856
Zhang, Jiandong; Rudemiller, Nathan P; Patel, Mehul B et al. (2016) Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol 27:2257-64
Richesson, Rachel L; Smerek, Michelle M; Blake Cameron, C (2016) A Framework to Support the Sharing and Reuse of Computable Phenotype Definitions Across Health Care Delivery and Clinical Research Applications. EGEMS (Wash DC) 4:1232

Showing the most recent 10 out of 37 publications