BB Principal Investigator/Program Director (Last, first, middle): DIETSCHY. John Maurice DESCRIPTION. State the application's broad, long-term objectives and specific aims,making reference to the health relatednessofthe project. Describe concisely the research design and methods for achieving thaj^pals.Avoid summaries of past accomplishments and the^e of the first person. This description is meant to serve as a succinct and accurate description^^ie proposed work when separated from the applic^^fc If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT^CCEED THE SPACE PROVIDED. Training in the UT Gastroenterology/Hepatology Research Training Program takes place in the laboratories of the Division of Digestive and Liver Diseases and in the laboratories of several basic science departments at The University of Texas Southwestern Medical Center and the Dallas Veteran's Affairs Medical Center campuses. Under the direction of Drs. John M. Dietschy, Stuart J. Spechler and Dwain L. Thiele, applicants are carefully screened and interviewed. Each successful applicant will undertake a major research project for two to four years under the direct supervision of one or more members of the Senior Research Faculty. In addition, each trainee will have close interactions with other Senior Research Faculty and with members of various basic science departments. The projects that are ongoing in the laboratories of these faculty members are very diverse and involve a wide variety of techniques in cellular and molecular biology. Representative projects include detailed studies into the nature of alternative biochemical pathways for the biosynthesis of bile acids, the role of orphan nuclear receptors in the control of bile acid synthesis and sterol transport, an analysis of new treatments for hepatitis C, the role of cytotoxic lymphocytes in diseases such as hepatitis and inflammatory bowel disease and the role of newly described cholesterol 24 hydroxylase and the ABCA1 protein in biliary cholesterol secretion. Initially all trainees attend formal lectures in the performance of ethical biological research and,throughout the year, participate in regular research conferences and clinical conferences in the division. In addition, there is a two year cycle of lectures devoted to the physiology, molecular biology and cell biology of the organs of the gastrointestinal tract. Throughout this two to four year course of intense research work, the trainees will learn to utilize a variety of basic laboratory procedures common to molecular and cell biology. If the trainee is engaged in clinical investigation, he/she will participate in a year long formal course in various aspects of human research. The progress of all trainees is monitored on a regular basis and, at the end of this intense period of research, each trainee will also have the opportunity of completing his/her clinical training. There are formal courses in the use of animals in medical research and in the special problems of ethical human investigation. There is an active program for recruiting underrepresented minorities. PERFORMANCE SITE ========================================Section End===========================================

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007745-09S1
Application #
7010487
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
1997-01-01
Project End
2006-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
9
Fiscal Year
2005
Total Cost
$59,493
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
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Rich, Nicole E; Oji, Stefany; Mufti, Arjmand R et al. (2018) Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 16:198-210.e2
Infante, Rodney Elwood; Radhakrishnan, Arun (2017) Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol. Elife 6:
Turer, Emre; McAlpine, William; Wang, Kuan-Wen et al. (2017) Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A 114:E1273-E1281
Pinzón, Jorge H; Reed, Addison R; Shalaby, Nevine A et al. (2017) Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. Alcohol Clin Exp Res 41:2015-2024
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Rahimi, Robert S; Rockey, Don C (2016) Overuse of Head Computed Tomography in Cirrhosis With Altered Mental Status. Am J Med Sci 351:459-66
Huebinger, Ryan M; Stones, Daniel H; de Souza Santos, Marcela et al. (2016) Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury. Sci Rep 6:39341
Zhang, Zhao; Turer, Emre; Li, Xiaohong et al. (2016) Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Proc Natl Acad Sci U S A 113:E6418-E6426

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