? This is an application for continued support of the training program in Pediatric Gastroenterology and Nutrition at the University of California, San Francisco (UCSF). The program has been funded continuously for the past 29 years, and represents the only NIH-supported training facility for this specialty in the Western US. The program objective is to prepare trainees for productive research in pediatric gastroenterology, hepatology and nutrition. The majority of graduates (70%) have proceeded to academic careers. Five years ago, this training grant was restructured to take advantage of the merger between UCSF and Stanford University. With dissolution of the merger, the program is reconfigured in recognition of the current academic environment that requires all trainees to understand molecular and genetic bases of pediatric disorders within the context of new modalities of health care services and value-based research. The program now strives to train highly selected prospects for academic pediatric gastroenterology to function within a team framework, coordinating the efforts of medical scientists with molecular and cell biologists, physiologists, bioengineers, ethnographers, and bioethicists. The current application proposes a more systematic and streamlined approach by (1) training within two primary career paths - Basic Research and Clinical Research - and (2) reducing the number of trainees in the program at any one time. Trainees receive 2-3 years of intensive didactic and practical instruction in basic laboratory or clinical research methods in the context of their own research project. The curriculum combines instruction in developmental aspects of gastrointestinal structure and function with practical experience in laboratory- and/or clinically-based research focused on biomechanisms of growth and differentiation, and disorders which interfere with orderly development. Educational exercises include formal lectures, seminars prepared by trainees, interdisciplinary presentations, and informal discussions of ongoing projects. Trainees attend courses in biostatistics, computer science, principles of bioresearch, and investigational ethics. Each trainee pursues an obligatory research project(s) supervised by experienced preceptors. Requirements are a MD degree and 3 years of residency in clinical pediatrics. Applicants with PhD degrees and defined career goals related to developmental gastroenterology or nutrition are also eligible. The program is administered in the Division of Pediatric Gastroenterology, Hepatology and Nutrition, but utilizes the scientific resources of the entire UCSF campus. Trainees have access to preceptors and laboratories, with associated training resources, in a multidisciplinary environment. Training program leadership is now centralized under the direct supervision of Dr. Melvin B. Heyman, supported by a new K24 grant for mentoring and clinical investigation. Key faculty include two Associate Directors, Core Divisional Faculty and Senior Faculty Mentors with professorial positions at UCSF. Support for 3 trainees per year is requested ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007762-28
Application #
6911554
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M2))
Program Officer
Podskalny, Judith M,
Project Start
1998-08-24
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
28
Fiscal Year
2005
Total Cost
$162,290
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Perito, Emily R; Phelps, Andrew; Vase, Tabitha et al. (2018) Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors. J Pediatr 193:119-127.e1
Verstraete, Sofia G; Wojcicki, Janet M; Perito, Emily R et al. (2018) Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in Hispanic adolescents in NHANES 2003-2010. Environ Health 17:12
Bayrer, James R; Wang, Hongtao; Nattiv, Roy et al. (2018) LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun 9:4055
Suh, Jung H; Degagné, Émilie; Gleghorn, Elizabeth E et al. (2018) Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study. Inflamm Bowel Dis 24:1321-1334
Perito, Emily R; Lustig, Robert H; Rosenthal, Philip (2017) Prediabetes in Pediatric Recipients of Liver Transplant: Mechanism and Risk Factors. J Pediatr 182:223-231.e3
de Schweinitz, Peter A; Wojcicki, Janet M (2017) First Nations Approaches to Childhood Obesity: Healthy Lifestyles in Canada Compared with Alternatives for Alaska Native Communities. Children (Basel) 4:
Perito, Emily R; Vase, Tabitha; Ramachandran, Rageshree et al. (2017) Hepatic steatosis after pediatric liver transplant. Liver Transpl 23:957-967
Wei, Liang; Kaul, Vandana; Qu, Xiumei et al. (2017) Absence of miR-182 Augments Cardiac Allograft Survival. Transplantation 101:524-530
Tsai, Yu-Hwai; Nattiv, Roy; Dedhia, Priya H et al. (2017) In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development 144:1045-1055
Wallach, Thomas E; Bayrer, James R (2017) Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology. J Pediatr Gastroenterol Nutr 64:180-185

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