This application is for 8th consecutive renewal of the Ruth L. Kirschstein National Research Service Award T32 Postdoctoral Research ?Training Program in Pediatric Gastroenterology/Nutrition? at the University of California, San Francisco (UCSF). More than 70% of graduates of UCSF Training Program in Pediatric Gastroenterology/Nutrition remain productive researchers and academic leaders in their respective fields The Program aims to train talented and dedicated young physicians to become independent and productive scientific investigators, and recent graduates have been successful in progressing along academic career development pathways. These future scientists will research important health problems, focusing on the causes, pathogenesis, and treatment of digestive, liver and nutritional disorders in infants and children. Preference is given to trainees committed to a 4-year training program, including 3 years of research training in either Basic (T1 track) or Clinical/Translational (T2 track) Research mentored by established scientists. The key elements of the proposed training are: (1) a mentored research experience, (2) scientific course work, (3) career development workshops, (4) interdisciplinary experiences and (5) ongoing review and evaluation. Basic research experience is supplemented with coursework, seminars, and inter-departmental retreats; trainees in clinical research participate in the well-established Training in Clinical Research Program that includes a 1-year Advanced Training in Clinical Research certificate, leading to a 2-year Master's Degree in Clinical Research program. Each trainee pursues an obligatory research project(s) supervised by experienced preceptors. All trainees take courses in Responsible Conduct in Research, Research Rigor and Reproducibility, Scientific Writing and the Art of Lecturing. The trainee and research mentor determine additional course work in the specific field of research. Entry requirements include a MD degree and 3 years of residency in clinical pediatrics. Applicants with a PhD degree and defined career goals related to developmental gastroenterology or nutrition are also eligible. Administration of the program is restructured to take advantage of the strengthened Division of Pediatric Gastroenterology/Nutrition under the primary direction of Dr. Melvin Heyman, associate direction from Dr. Philip Rosenthal, and mentored assistant direction from Drs. James Bayrer and Emily Perito. The quality of educational and research programs and activities are closely monitored by trainee mentors, research preceptors, Internal Advisors, the Assistant Program Directors, the Associate Program Director, the Program Director, and annual evaluations by distinguished External Advisors. An increase from 3 to 5 training positions is requested in Years 41-45.

Public Health Relevance

This Program is directly relevant to child health and development in training the next generation of scientists who will generate the advances essential for improving the quality of life and survival rates of children and adolescents with gastrointestinal, liver and nutrition-related disorders. Further, this training program represents an investment in the future of public health in general, as the multidisciplinary, intensive and innovative training provided by this Program will educate the leaders, teachers, and professional role models who will determine the direction and contributions of American medicine domestically and throughout the world, particularly as relates to pediatric gastroenterology, hepatology and nutrition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007762-43
Application #
9963193
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1998-08-24
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
43
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Perito, Emily R; Phelps, Andrew; Vase, Tabitha et al. (2018) Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors. J Pediatr 193:119-127.e1
Verstraete, Sofia G; Wojcicki, Janet M; Perito, Emily R et al. (2018) Bisphenol a increases risk for presumed non-alcoholic fatty liver disease in Hispanic adolescents in NHANES 2003-2010. Environ Health 17:12
Bayrer, James R; Wang, Hongtao; Nattiv, Roy et al. (2018) LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun 9:4055
Suh, Jung H; Degagné, Émilie; Gleghorn, Elizabeth E et al. (2018) Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study. Inflamm Bowel Dis 24:1321-1334
Krams, S M; Schaffert, S; Lau, A H et al. (2017) Applying Mass Cytometry to the Analysis of Lymphoid Populations in Transplantation. Am J Transplant 17:1992-1999
Wojcicki, Janet M; de Schweinitz, Peter (2017) Store owners as potential agents of change: energy drinks in the interior of Alaska. Int J Circumpolar Health 76:1400362
Perito, Emily R; Ajmera, Veeral; Bass, Nathan M et al. (2017) Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun 1:609-622
Fox, Cade B; Nemeth, Cameron L; Chevalier, Rachel W et al. (2017) Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading. Bioeng Transl Med 2:9-16
Fernandes, Melissa A; Braun, Hillary J; Evason, Kim et al. (2017) De novo inflammatory bowel disease after pediatric kidney or liver transplant. Pediatr Transplant 21:
Perito, Emily R; Lustig, Robert H; Rosenthal, Philip (2017) Prediabetes in Pediatric Recipients of Liver Transplant: Mechanism and Risk Factors. J Pediatr 182:223-231.e3

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