The GI Training Program at UVa continues to be committed to developing investigators dedicated to careers in academic gastroenterology. The foundation of this training program is a robust research environment, which has grown steadily over the past 5 years in size, funding, and productivity. The program is designed to produce a new generation of high quality academic investigators in gastroenterology. Fundamental features of the post-doctoral training curriculum include participation in direct basic and clinical research and a comprehensive program of didactic instruction and enrichment activities aimed at providing a solid foundation in biomedical sciences as well as the latest research techniques. Research Areas and Disciplines: A central feature of the training program is the leadership of enthusiastic investigators applying state-of-the-art techniques to fundamental questions in gastrointestinal health and disease. The broad range of research interests of the faculty is unified by a core of related disciplines, which are common to every trainee's experience. The majority of trainees will undergo training in laboratory research, applying the tools of molecular biology, genetics, and immunology to important GI questions. Training is offered in several disciplines: Immunology, Molecular Biology, Signal Transduction, Physiology, Cancer Biology, Genetics, and Epidemiology/Health Evaluation Sciences. For the trainees pursuing clinical investigation, a rigorous curriculum in quantitative sciences, including Outcomes Research, Biostatistics, Epidemiology, and Clinical Trials is also available in collaboration with the Health Evaluations Sciences faculty. Level of Training, Background, and Number of Trainees: This continuation application is focused on post-doctoral training offered to individuals holding M.D., Ph.D., or relevant degrees. Four post-doctoral positions are requested, with 2 beginning training each year and remaining in training supported by this award for a minimum of 2 years. Due to the success of our program, we are requesting to increase the total number of positions by one position. Four 10-week summer pre-doctoral positions are also requested to expand our program. Training Facilities: Research training will take place in the existing laboratories of the research mentors, a group of established investigators with extensive collaborative interactions. Laboratories are located in the Digestive Health Research Center, which is part of the UVa Health System campus that includes almost 500,000 square feet of state-of-the-art research space. Past Accomplishments and Impact on Digestive Health Research: This training grant has been instrumental in the development of digestive health research at UVa. During the past funding period, we have supported 9 trainees. Five are currently still engaged in training. Three of the 4 individuals who have finished training have taken academic positions as assistant professors and 1 has entered medical school. Of our 9 trainees, 2 were women and 2 were minorities. All 5 trainees currently in training are planning to pursue careers in academic medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007769-10
Application #
7472472
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1999-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
10
Fiscal Year
2008
Total Cost
$151,229
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Stine, Jonathan G; Northup, Patrick G; Stukenborg, George J et al. (2018) Geographic variation in liver transplantation persists despite implementation of Share35. Hepatol Res 48:225-232
Stine, Jonathan G; Wang, Jennifer; Shah, Puja M et al. (2018) Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study. Liver Int 38:94-101
Stine, Jonathan G; Chalasani, Naga P (2017) Drug Hepatotoxicity: Environmental Factors. Clin Liver Dis 21:103-113
Harakal, Jessica; Rival, Claudia; Qiao, Hui et al. (2016) Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis. J Immunol 197:27-41
Stine, Jonathan G; Lewis, James H (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Rev Gastroenterol Hepatol 10:517-36
Stine, Jonathan G; Wang, Jennifer; Behm, Brian W (2016) Chronic Cholestatic Liver Injury Attributable to Vedolizumab. J Clin Transl Hepatol 4:277-280
Stine, Jonathan G; Pelletier, Shawn J; Schmitt, Timothy M et al. (2016) Pre-transplant portal vein thrombosis is an independent risk factor for graft loss due to hepatic artery thrombosis in liver transplant recipients. HPB (Oxford) 18:279-86
Stine, Jonathan G; Argo, Curtis K; Pelletier, Shawn J et al. (2016) Liver transplant recipients with portal vein thrombosis receiving an organ from a high-risk donor are at an increased risk for graft loss due to hepatic artery thrombosis. Transpl Int 29:1286-1295
Maiden, Stephanie L; Petrova, Yuliya I; Gumbiner, Barry M (2016) Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. PLoS One 11:e0148574
Stine, Jonathan G; Shah, Puja M; Cornella, Scott L et al. (2015) Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World J Hepatol 7:2774-80

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