This application is a request for renewal of the Hematopoiesis Training Grant of the University of Pennsylvania. The program consists of 4 post-doctoral and 2pre-doctoral positions for training in aspects of normal and malignant hematopoiesis. We are requesting one additional pre-doctoral position of a M.D./Ph.D. candidate to meet the requests for additional opportunities for this group of trainees. The program currently has 21trainers with trainers added in the areas of malignant hematopoiesis and hematopoiesis of aging. The Hematopoiesis Training Program is a multi-disciplinary, cross departmental training program drawing on the extensive resources of the University of Pennsylvania School of Medicine, Children's Hospital of Pennsylvania and the Wistar Institute. The academicelements of the training program include a proven mixture of coursework, laboratory work, research presentations, thesis research, career development counseling and extramural conferences that combine to train new investigators in the fundamentals of blood development. The assembles trainers for this grant have extensive and highly productive training records in the area of hematopoiesis and substantial research support through both individual grants and program projects. These laboratories offer training opportunities across virtually all aspects ofhematopoietic cell development and function. The Hematopoiesis research group draws candidates from several graduate programs at the University of Pennsylvania and post-doctoral applicants Tom around the world. The program focuses specifically on training individuals to have a broad and deep understanding of the fundamentals of hematopoiesis with a goal of developing successful researchers in this important area of biology.

Public Health Relevance

Blood diseases are common disorders that affect all populations of the United States. This application will rain researchers to better understand how blood cells develop and generate new treatments for diseases of he blood and blood cells.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Bishop, Terry Rogers
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University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
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Yzaguirre, Amanda D; Howell, Elizabeth D; Li, Yan et al. (2018) Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis. Development 145:
Behera, Vivek; Evans, Perry; Face, Carolyne J et al. (2018) Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility. Nat Commun 9:782
Li, Ting; Wang, Wei; Gong, Shunyou et al. (2018) Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism. Mol Immunol 99:154-162
Emptage, Ryan P; Lemmon, Mark A; Ferguson, Kathryn M et al. (2018) Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. Structure 26:1137-1143.e3
Fang, Pu; Li, Xinyuan; Dai, Jin et al. (2018) Immune cell subset differentiation and tissue inflammation. J Hematol Oncol 11:97
Mowel, Walter K; Kotzin, Jonathan J; McCright, Sam J et al. (2018) Control of Immune Cell Homeostasis and Function by lncRNAs. Trends Immunol 39:55-69
Rech, Andrew J; Dada, Hannah; Kotzin, Jonathan J et al. (2018) Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint Blockade in Cancer. Cancer Res 78:4282-4291
Nelson, Caroline A; Noe, Megan H; McMahon, Christine M et al. (2018) Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center. J Am Acad Dermatol 78:303-309.e4
Tang, Alan T; Choi, Jaesung P; Kotzin, Jonathan J et al. (2017) Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature 545:305-310
Kotzin, Jonathan J; Mowel, Walter K; Henao-Mejia, Jorge (2017) Viruses hijack a host lncRNA to replicate. Science 358:993-994

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