? The goal of this Gastroenterology Research Training Program is to prepare M.D., Ph.D., or M.D./Ph.D. postdoctoral fellows for careers as independent investigators in academic Gastroenterology. A diverse Faculty has therefore been selected who can offer trainees the greatest opportunity to learn contemporary methods of cellular and molecular biology or clinical investigation, and to mentor trainees in a number of broad areas of research, including A) Injury, Fibrosis Signaling & Gene Regulation; B) Cancer Biology & Genetics, and Immunology; C) Molecular Basis of Transport, Metabolism, Development & Gene Therapy; or D) Patient-based Clinical Investigation in Hepatobililary and Gastrointestinal Diseases. It is our belief that the extensive experience gained in any one of these areas should provide trainees with a solid foundation for future success in investigative Gastroenterology. To provide this diversity we have recruited faculty with expertise in these areas from the Divisions of Gastroenterology and Liver Diseases, four other Divisions in the Department of Medicine (Immunology, Pulmonary, Endocrinology, and Hematology/Oncology) and other clinical and basic Departments and Centers within the School of Medicine (Pediatrics, Surgery, Biochemistry & Pharmacology, Cell & Molecular Medicine, Oncological Sciences, Health Policy, and the Transplantation Institute). ? Throughout the training period MD trainees will devote approximately 90% of their time to research; Ph.D. trainees will concentrate 100% of their efforts. The primary focus and vast majority of the trainee's time will be devoted to working in the laboratory or patient-care setting on a specific, individualized research project under the guidance of one or more mentors who are faculty of this training program, in cooperation with a Scholarship Oversight Committee. In addition to working at the bench, laboratory trainees will participate in weekly laboratory meetings of their preceptor. Patient-based trainees will be required to participate in the K30 curriculum leading to a Masters in Clinical Research. Trainees will be expected to spend a portion of their time attending specific divisional, departmental and institutional research-oriented conferences. For those trainees still awaiting Gl Board eligibility, trainees will be expected to attend the weekly Gastroenterology and Liver Division Clinical Conferences, and will attend one continuity clinic per week to satisfy Board requirements. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007792-06A1
Application #
7124467
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (M1))
Program Officer
Densmore, Christine L
Project Start
2001-05-01
Project End
2011-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
6
Fiscal Year
2006
Total Cost
$157,177
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Mosoian, Arevik; Zhang, Lumin; Hong, Feng et al. (2017) Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS. J Leukoc Biol 101:1083-1090
Cohen, Louis J; Esterhazy, Daria; Kim, Seong-Hwan et al. (2017) Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549:48-53
Bollard, Julien; Miguela, Verónica; Ruiz de Galarreta, Marina et al. (2017) Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut 66:1286-1296
Shtraizent, Nataly; DeRossi, Charles; Nayar, Shikha et al. (2017) MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. Elife 6:
Wooden, Benjamin; Goossens, Nicolas; Hoshida, Yujin et al. (2017) Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases. Gastroenterology 152:53-67.e3
Klepper, Arielle; Eng, Francis J; Doyle, Erin H et al. (2017) Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells. Hepatology 66:357-370
Hicks, Daniel F; Goossens, Nicolas; Blas-García, Ana et al. (2017) Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. Sci Rep 7:42563
Tovar, Victoria; Cornella, Helena; Moeini, Agrin et al. (2017) Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma. Gut 66:530-540
Abou-Alfa, Ghassan K; Andersen, Jesper B; Chapman, William et al. (2016) Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. J Gastrointest Oncol 7:819-827
Chu, John; Vila-Farres, Xavier; Inoyama, Daigo et al. (2016) Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol 12:1004-1006

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