This is a proposal for a research training program for post-doctoral trainees in Nephrology and Hypertension. The goal is to prepare physicians and scientists to undertake independent investigation in renal and hypertensive disorders and in the basic biology which underlies normal and aberrant kidney function or blood pressure regulation. We emphasize application of cutting edge basic research techniques to health related problems of renal and hypertensive disease that include studies of renal mechanisms of blood pressure and volume homeostasis, receptor regulation, vascular physiology, pharmacology and angiogenesis, intracellular signaling, oxidative stress, effects of gender and pregnancy on vascular function, molecular genetics and interactions between vasoactive factors in the kidney. Candidates will have the MD and/or PhD. Physicians will have completed clinical training in either internal medicine or pediatrics and most will undertake clinical subspecialty training in nephrology. The research training program will be for 2 years, during which patient care activities will be strictly limited. Candidates will be selected by the entire faculty based upon stated career goals in research and academic nephrology, interviews, letters of recommendation, and past performance. Progress of candidates will be assessed by the program director and co-director, individual faculty preceptors, review by the training faculty and review of formal presentations and written progress reports. All training will be carried out at Georgetown University Medical Center, in the laboratories of a cohesive and highly collaborative group of training faculty drawn from the Departments of Medicine, Pediatrics, Pharmacology, Physiology, and Oncology. Five of the seven core faculty are the Pi's of an NIH Program Project Grant. They undertake research supported by core facilities. The training and support faculty are drawn from many departments in the newly formed Cardiovascular Kidney Institute. This provides a cohesive and collaborative research environment in which to provide basic science research training for selected trainees.
The aim i s to train physicians and post doctoral scientists, for a career in academic nephrology and hypertension.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK059274-09
Application #
7929625
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2001-09-01
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
9
Fiscal Year
2010
Total Cost
$75,355
Indirect Cost
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Li, Lingli; Feng, Di; Luo, Zaiming et al. (2015) Remodeling of Afferent Arterioles From Mice With Oxidative Stress Does Not Account for Increased Contractility but Does Limit Excessive Wall Stress. Hypertension 66:550-6
Luo, Zaiming; Aslam, Shakil; Welch, William J et al. (2015) Activation of nuclear factor erythroid 2-related factor 2 coordinates dimethylarginine dimethylaminohydrolase/PPAR-?/endothelial nitric oxide synthase pathways that enhance nitric oxide generation in human glomerular endothelial cells. Hypertension 65:896-902
Wang, Cheng; Luo, Zaiming; Kohan, Donald et al. (2015) Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease. Hypertension 65:1055-63
Lai, En Yin; Luo, Zaiming; Onozato, Maristela L et al. (2012) Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. Am J Physiol Renal Physiol 303:F64-74
Wang, Dan; Luo, Zaiming; Wang, Xiaoyan et al. (2010) Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol. Hypertension 56:950-5
Luo, Zaiming; Teerlink, Tom; Griendling, Kathy et al. (2010) Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells. Hypertension 56:498-504
Luo, Z; Chen, Y; Chen, S et al. (2009) Comparison of inhibitors of superoxide generation in vascular smooth muscle cells. Br J Pharmacol 157:935-43
Teerlink, Tom; Luo, Zaiming; Palm, Fredrik et al. (2009) Cellular ADMA: regulation and action. Pharmacol Res 60:448-60
Wilcox, Christopher S; Pearlman, Adam (2008) Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev 60:418-69
Kulick, Aaron; Panico, Carolina; Gill, Pritmohinder et al. (2008) Low salt intake increases adenosine type 1 receptor expression and function in the rat proximal tubule. Am J Physiol Renal Physiol 295:F37-41

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