Liver disease is among the ten most important causes of death in the United States. However, over the last 10-15 years, there has been a remarkable expansion of basic knowledge in liver biology. This knowledge has led to new modalities for managing the various forms of acute and chronic liver disease. Treatments of viral hepatitis and liver transplantation have captured the headlines, but considerable progress has occurred also in therapy of portal hypertension, gene transfer, and cell transplantation for genetic liver disease, bioartificial liver support for acute liver failure, pathogenesis and therapy of cholestatic diseases, antifibrotic therapy and many others. The extraordinary progress has created a demand for well-trained hepatologists, in particular those who both contribute to current advances in basic knowledge and take disease management to the next level. While progress has been impressive, hepatitis C, hepatocellular carcinoma, and obesity-related liver disease (nonalcoholic steatohepatitis, or NASH) are looming epidemics, for which liver transplantation will not be a realistic solution for all, given the limitation of organ supply. Therefore, we see the training of research hepatologists as a national priority. The Division of Gastroenterology at UCSF has a 30 year history of preeminence in the research and treatment of liver diseases, with an NIH-funded Liver Center since 1975 and, since 1988, a Liver Transplant Program in partnership with the Department of Surgery. Through the Liver Center and joint mentorship of trainees, the Division is closely allied also with the basic sciences at UCSF and the Immunology Program in particular. This application is for funds for a two-year training experience in clinical or basic research, for two individuals annually, in Advanced Hepatology. The program faculty represents the Departments of Immunology/ Microbiology and Pathology as well as Medicine and Surgery. Fellows who select clinical research will receive formal training in clinical/outcomes methodology, with an option to earn an MS or MPH degree. Those in basic or translational laboratory research have a broad array of possibilities with formal courses and a richly supportive environment. Each trainee will have an individual oversight committee to review progress and provide feedback. Graduates of the program will have a productive research program and be fully prepared for a junior faculty position and ideally trained to successfully apply for NIH funding.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Cullaro, Giuseppe; Park, Meyeon; Lai, Jennifer C (2018) ""Normal"" Creatinine Levels Predict Persistent Kidney Injury and Waitlist Mortality in Outpatients With Cirrhosis. Hepatology 68:1953-1960
Ajmera, Veeral; Belt, Patricia; Wilson, Laura A et al. (2018) Among Patients With Nonalcoholic Fatty Liver Disease, Modest Alcohol Use Is Associated With Less Improvement in Histologic Steatosis and Steatohepatitis. Clin Gastroenterol Hepatol 16:1511-1520.e5
Cullaro, Giuseppe; Sarkar, Monika; Lai, Jennifer C (2018) Sex-based disparities in delisting for being ""too sick"" for liver transplantation. Am J Transplant 18:1214-1219
Cullaro, Giuseppe; Pisa, Joseph F; Brown Jr, Robert S et al. (2018) Early Postoperative Neutrophil Gelatinase-Associated Lipocalin Predicts the Development of Chronic Kidney Disease After Liver Transplantation. Transplantation 102:809-815
Kotwani, Prashant; Saxena, Varun; Dodge, Jennifer L et al. (2018) History of Marijuana Use Does Not Affect Outcomes on the Liver Transplant Waitlist. Transplantation 102:794-802
Cullaro, Giuseppe; Hirose, Ryutaro; Lai, Jennifer C (2018) Changes in Simultaneous Liver Kidney Transplant Allocation Policy May Impact Post Liver Transplant Outcomes. Transplantation :
Lee, Brian P; Mehta, Neil; Platt, Laura et al. (2018) Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis. Gastroenterology 155:422-430.e1
Lee, Brian P; Terrault, Norah A (2018) Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus. Curr Opin Organ Transplant 23:229-236
Ajmera, Veeral H; Terrault, Norah A; Harrison, Stephen A (2017) Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review. Hepatology 65:2090-2099
Perito, Emily R; Ajmera, Veeral; Bass, Nathan M et al. (2017) Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun 1:609-622

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