This is an application to renew support for the Baylor College of Medicine (BCM) Hematology Training Program (HTP) that has been successfully running for 10 years and has trained, or is training, 41 young investigators, 11 of whom are from under-represented minority groups. Of past trainees, 13 are academic faculty performing biomedical research and 16 are still in training. The trainees have published a total of 107 papers directly related to their hematology training. The overall goal of the Hematology Training Program is to foster hematology research by training the most talented young investigators at the pre-doc and post-doc level. Training is provided to researchers in both adult and pediatric hematology who include MD, MD/PhD and PhD trainees, as well as basic researchers performing hematology-related research in diverse departments. The BCM HTP provides its trainees with the mentorship, research skills and experience to ultimately become productive and successful investigators in the field. The program is structured to ensure close mentorship from accomplished senior researchers at Baylor College of Medicine, and to support junior faculty to develop their own mentorship skills. The 33 faculty mentors participating in the HTP have broad teaching and training experience and share a commitment to train young scientists and physician-scientists in hematology research. Their expertise covers a wide range of hematology research areas including stem cell biology, hemoglobin function, iron metabolism, thrombosis, neutrophil function, myeloid cell differentiation, stem cell transplantation and cell and gene therapy. Important components of the BCM HTP are a structured training scheme involving mentored research, a didactic program, and preparation for grant writing. The PI and Co-Directors, Margaret Goodell, David Poplack, and Martha Mims have a history of close productive interaction with each other and a strong record of past trainees, assuring a close interaction and integration of basic research with clinical adult and pediatric hematology programs. Renewal of the Hematology Training Program will ensure continued training of outstanding physician-scientists in hematology at BCM.

Public Health Relevance

This program is designed to train young investigators to conduct hematology-related research. Trainees may conduct basic or translational research, with a view to entering a career in academic biomedical research and impacting the course of diseases related to hematology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK060445-13
Application #
9087244
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Bishop, Terry Rogers
Project Start
2002-09-30
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Kruse, Robert L; Shum, Thomas; Tashiro, Haruko et al. (2018) HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. Cytotherapy 20:697-705
Hogstad, Brandon; Berres, Marie-Luise; Chakraborty, Rikhia et al. (2018) RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. J Exp Med 215:319-336
Fasipe, Titilope A; Hong, Sung-Ha; Da, Qi et al. (2018) Extracellular Vimentin/VWF (von Willebrand Factor) Interaction Contributes to VWF String Formation and Stroke Pathology. Stroke 49:2536-2540
Yan, Hannah; Baldridge, Megan T; King, Katherine Y (2018) Hematopoiesis and the bacterial microbiome. Blood 132:559-564
Jeong, Mira; Park, Hyun Jung; Celik, Hamza et al. (2018) Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. Cell Rep 23:1-10
Ballester, Leomar Y; Cantu, Miguel D; Lim, Karen P H et al. (2018) The use of BRAF V600E mutation-specific immunohistochemistry in pediatric Langerhans cell histiocytosis. Hematol Oncol 36:307-315
Chapple, Richard H; Tseng, Yu-Jung; Hu, Tianyuan et al. (2018) Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis. Blood Adv 2:1220-1228
Chapple, Richard H; Hu, Tianyuan; Tseng, Yu-Jung et al. (2018) ER? promotes murine hematopoietic regeneration through the Ire1?-mediated unfolded protein response. Elife 7:
Arasaratnam, R J; Tzannou, I; Gray, T et al. (2018) Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients. Am J Transplant 18:2238-2249
Matatall, Katie A; Kadmon, Claudine S; King, Katherine Y (2018) Detecting Hematopoietic Stem Cell Proliferation Using BrdU Incorporation. Methods Mol Biol 1686:91-103

Showing the most recent 10 out of 95 publications