The goal of this training program is to prepare predoctoral students, physicians and PhDs for biomedical research careers by providing a concentrated, in-depth research experience. Our program will provide support for three trainees per year, with a mix of one renal fellow, and one non-clinical PhD trainee, and one predoctoral student. This program is designed to foster a rigorous approach to scientific inquiry in basic science or clinical investigation. Four areas of research are emphasized: (1) renal/epithelial transport;(2) epithelial cell biology;(3) cell signaling/kidney development/renal pathophysiology/immunology;and (4) renal epidemiology/clinical research/genetics. Our training program faculty are members of the University of Pittsburgh. Together they form a well-integrated and collaborative entity dedicated to research training and investigation in nephrology, epithelial biology, renal pathophysiology, immunology, epidemiology and clinical research. Trainees will develop a research project under the close supervision of a faculty trainer and will be closely monitored by an independent advisory or thesis committee as well as by the research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work, and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this comprehensive training experience will be equipped to compete for individual training support. Postdoctoral graduates of this program will be prepared to compete for independent funding and entry-level faculty positions in academic medicine.
There have been tremendous advances in biomedical sciences over the past several decades that should enhance our ability to diagnose, treat and prevention of kidney diseases. However, we still face challenges in advancing our understanding of kidney physiology and of diseases of the kidney, as well as our ability to translate these remarkable basic science discoveries into new drugs and treatments for patients. The main objective of our training program is to provide an intensive and structured research experience for both physicians and non-physician trainees in order to foster the development of the skills needed to pursue a successful career in the areas of investigative nephrology and epithelial biology.
| Preston, G Michael; Guerriero, Christopher J; Metzger, Meredith B et al. (2018) Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation. Mol Cell 70:242-253.e6 |
| Espiritu, Eugenel B; Crunk, Amanda E; Bais, Abha et al. (2018) The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Sci Rep 8:16029 |
| Blobner, Brandon M; Wang, Xue-Ping; Kashlan, Ossama B (2018) Conserved cysteines in the finger domain of the epithelial Na+ channel ? and ? subunits are proximal to the dynamic finger-thumb domain interface. J Biol Chem 293:4928-4939 |
| Boyd-Shiwarski, Cary R; Shiwarski, Daniel J; Roy, Ankita et al. (2018) Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Mol Biol Cell 29:499-509 |
| Ray, Evan C; Miller, Rachel G; Demko, John E et al. (2018) Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension. Kidney Int Rep 3:1434-1442 |
| Jobbagy, Soma; Tan, Roderick J (2018) Nitrolipids in kidney physiology and disease. Nitric Oxide : |
| Eshbach, Megan L; Sethi, Rahil; Avula, Raghunandan et al. (2017) The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line. Am J Physiol Renal Physiol 313:F585-F595 |
| Unruh, Mark L; Pankratz, V Shane; Demko, John E et al. (2017) Trial of Amiloride in Type 2 Diabetes with Proteinuria. Kidney Int Rep 2:893-904 |
| Preston, G Michael; Brodsky, Jeffrey L (2017) The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. Biochem J 474:445-469 |
| Boyd-Shiwarski, Cary R; Subramanya, Arohan R (2017) The renal response to potassium stress: integrating past with present. Curr Opin Nephrol Hypertens 26:411-418 |
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