This application is a proposal for a Fellowship training program in pediatric endocrinology, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), and the Children's Hospital Colorado (CHC) at the University of Colorado School of Medicine. It also proposes to train post-doctoral psychologists in diabetes behavioral research. The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists and psychologists trained in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. Psychologists training in behavioral research beside physicians will add strength to the physician program and contribute diabetes research trained psychologists to the very small pool of these important specialists. The Barbara Davis Center and CHC have an extensive and a proven record in research training of young investigators. A strong endocrinology program at Children's Hospital, in addition to research program in type 2 diabetes, will provide a well-rounded pediatric endocrinology training program. The BDC, CHC and the wider Anschutz Medical Campus (AMC) have well- established investigators in the epidemiology, pathophysiology, immunobiology, genetics, and molecular biology of type 1 and type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists prepared for a career as diabetes investigators. Areas of research focus within the Barbara Davis Center include developmental islet cell biology, genetics, immunology, autoimmunity, prediction and prevention of type 1 diabetes, as well as the epidemiology of and improved, novel treatments of type 1 and type 2 diabetes. The integration of psychologists training in diabetes behavioral research will add importance and depth to the Program. These areas of research are urgently needed and have been identified as important to the national public health to address diabetes in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Research Institute (CCTSI), Pediatric Clinical Translational Research Center, as well as a strong Masters of Clinical Science within the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, the CCTSI and Children's Hospital Colorado. The ability to provide strong didactic courses in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, molecular biology, as well as human molecular genetics through the CCTSI, the BDC and the CSPH, combined with a strong mentoring faculty will allow us to provide the training required to develop pediatric endocrinologists and psychologists into the scientists needed for the leaders of tomorrow.

Public Health Relevance

Our NIDDK T32 Training Program ?Developing Pediatric Endocrinologists and Diabetes Psychologists for the Future? will be conducted at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine and Children's Hospital Colorado, Anschutz Medical Campus. Our PRINCIPAL OBJECTIVE is to develop Pediatric Endocrinologists and Psychologists who are well grounded in basic and/or translational science research skills required for advancing the field of knowledge in type 1 and type 2 diabetes and are educated in collaborative and integrated approaches for translating basic discoveries in diabetes into opportunities for advancing clinical research and care. Our OVERALL GOAL is that after their training, our trainees will have acquired the professional skills to become clinician scientists beginning productive academic careers as junior faculty investigators who will have the leadership capacity to make significant impacts in the fields of type 1 and type 2 diabetes in children and adolescents.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
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Castle, Arthur
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University of Colorado Denver
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United States
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Lovshin, Julie A; Boulet, Geneviève; Lytvyn, Yuliya et al. (2018) Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes. JCI Insight 3:
Bjornstad, Petter; Donaghue, Kim C; Maahs, David M (2018) Macrovascular disease and risk factors in youth with type 1 diabetes: time to be more attentive to treatment? Lancet Diabetes Endocrinol 6:809-820
Bjornstad, Petter; Pyle, Laura; Cherney, David Z I et al. (2018) Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant 33:1189-1196
Tonneijck, Lennart; Muskiet, Marcel H A; Smits, Mark M et al. (2018) Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and kidney clearance: Post-hoc analyses of four clinical trials. Diabetes Obes Metab 20:1235-1245
Cree-Green, Melanie; Stuppy, Jacob J; Thurston, Jessica et al. (2018) Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab 103:3647-3657
Lovshin, Julie A; Škrti?, Marko; Bjornstad, Petter et al. (2018) Hyperfiltration, urinary albumin excretion, and ambulatory blood pressure in adolescents with Type 1 diabetes mellitus. Am J Physiol Renal Physiol 314:F667-F674
Bjornstad, Petter; Laffel, Lori; Tamborlane, William V et al. (2018) Acute Effect of Empagliflozin on Fractional Excretion of Sodium and eGFR in Youth With Type 2 Diabetes. Diabetes Care 41:e129-e130
Cree-Green, Melanie; Scalzo, Rebecca L; Harrall, Kylie et al. (2018) Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes 67:1369-1379
Bjornstad, Petter; Lovshin, Julie A; Lytvyn, Yuliya et al. (2018) Adiposity Impacts Intrarenal Hemodynamic Function in Adults With Long-standing Type 1 Diabetes With and Without Diabetic Nephropathy: Results From the Canadian Study of Longevity in Type 1 Diabetes. Diabetes Care 41:831-839
Bernabé, K J; Nokoff, N J; Galan, D et al. (2018) Preliminary report: Surgical outcomes following genitoplasty in children with moderate to severe genital atypia. J Pediatr Urol 14:157.e1-157.e8

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