The goal of the training program is to prepare physicians and pre- and post- doctoral trainees for biomedical research careers in digestive diseases by providing concentrated, structured and well-mentored research training. The program will provide training to 4 postdoctoral fellows and 1 predoctoral student with an overall mix of 2-3 physician-scientists and 1-2 translational/basic research postdoctoral trainees per year. The program offers opportunities in four basic Research Training Units that reflect the clinical Centers of Excellence in the Digestive Disorder Center leveraged against the basic science strengths of the University of Pittsburgh. The training units include: 1) Inflammatory Bowel Diseases, 2) Neurogastroenterology and Motility, 3) Pancreas, Biliary and Liver Diseases, and 4) Gl Cancers. Transecting these units are scientific disciplines of genetics, immunology, neuroscience, molecular and cellular biology, and epidemiology. The training faculty are [sic] all members of the University of Pittsburgh and characterized by R01 funding, excellent training records, productive collaborations and a dedication to understanding the pathophysiology of digestive diseases. Together they form a close and well-integrated entity dedicated to research training and investigations in gastroenterology, hepatology, pancreatic and nutritional disorders, with research foci ranging from small molecules to global human populations. Trainees will develop a research project under the close supervision of a faculty trainer and will be monitored by an advisory group or thesis committee as well as by a research training executive committee. Didactic lectures, research seminars, journal clubs, formal course work and attendance at scientific meetings will supplement this intensively structured research experience. Predoctoral graduates of this training program will be equipped to compete for individual training support. Postdoctoral graduates will be prepared to compete for independent funding and entry level faculty positions in academic medicine.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Click, Benjamin; Pinsky, Paul F; Hickey, Tom et al. (2018) Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence. JAMA 319:2021-2031
Regueiro, Miguel; Click, Benjamin; Anderson, Alyce et al. (2018) Reduced Unplanned Care and Disease Activity and Increased Quality of Life After Patient Enrollment in an Inflammatory Bowel Disease Medical Home. Clin Gastroenterol Hepatol 16:1777-1785
Makadia, Payal A; Najjar, Sarah A; Saloman, Jami L et al. (2018) Optogenetic Activation of Colon Epithelium of the Mouse Produces High-Frequency Bursting in Extrinsic Colon Afferents and Engages Visceromotor Responses. J Neurosci 38:5788-5798
Chao, David T; Shah, Nilesh H; Zeh 3rd, Herbert J et al. (2018) Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age. Gastroenterol Res Pract 2018:2380596
Phillips, Anna Evans; Shah, Nilesh; Borhani, Amir A et al. (2018) Prior History of Pancreatitis Accelerates the Development of Pancreatic Adenocarcinoma. Pancreas 47:1262-1266
Zhan, Wei; Shelton, Celeste A; Greer, Phil J et al. (2018) Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. Pancreas 47:924-936
Pradhan-Sundd, Tirthadipa; Zhou, Lili; Vats, Ravi et al. (2018) Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology 67:2320-2337
Click, Benjamin; Anderson, Alyce M; Ramos Rivers, Claudia et al. (2018) Telephone Encounters Predict Future High Financial Expenditures in Inflammatory Bowel Disease Patients: A 3-Year Prospective Observational Study. J Clin Gastroenterol 52:319-325
Phillips, Anna E; Papachristou, Georgios I; Slivka, Adam (2017) Consideration of Clinical Context and Alternative Therapies in Aggressive Resuscitation for Prevention of Post-ERCP Pancreatitis. J Clin Gastroenterol :
Rao, Bhavana B; Click, Benjamin H; Koutroubakis, Ioannis E et al. (2017) The Cost of Crohn's Disease: Varied Health Care Expenditure Patterns Across Distinct Disease Trajectories. Inflamm Bowel Dis 23:107-115

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