The goal of the program is to provide training to young researchers, at both the pre-doctoral and postdoctoral stages of their careers, in research that is relevant to diabetes, metabolism, and obesity. The Indiana University School of Medicine is an outstanding forum for such an initiative. Twenty two faculty from four Departments will participate as mentors in the program. This group of faculty has a strong training record and has over $7,500,000 of external funding. The program supports two pre-doctoral students and two post-doctoral fellows, and has successfully trained three students and two post-doctoral fellows over the four year period covered by this application. Pre-doctoral students will take a Minor in Diabetes and Obesity which includes a course in Diabetes and Obesity. Post-doctoral fellows will also take the course. Both students and post-doctoral fellows will attend Center for Diabetes Research seminars, will present their results in the same series, and will be encouraged to present their work at national meetings such as the American Diabetes Association scientific sessions. Additionally, they will take the Research Ethics course (G505). By training in an environment and culture that gives strong multi-disciplinary support for diabetes research, there is a significant probability that the trainees will sustain an interest in diabetes, even as their specific research interests evolve over their careers. Relevance. Diabetes mellitus is one of the predominant causes of premature loss of life in the United States and other developed countries. Furthermore, the incidence of type 2 diabetes is on the increase to the extent that it can be considered an epidemic in this country and one in three children born in 2003 is predicted to be afflicted with the disease in their lifetime. Therefore, it is important to provide training in the area of diabetes research with the goal of increasing the number of young researchers committed to careers confronting this common disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
Zip Code
Tersey, Sarah A; Levasseur, Esther M; Syed, Farooq et al. (2018) Episodic ?-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice. FASEB J :fj201800150RR
Lakhter, Alexander J; Pratt, Rachel E; Moore, Rachel E et al. (2018) Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes. Diabetologia 61:1124-1134
Sims, Emily K; Lakhter, Alexander J; Anderson-Baucum, Emily et al. (2017) MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. Diabetologia 60:1057-1065
Hernandez-Perez, Marimar; Chopra, Gaurav; Fine, Jonathan et al. (2017) Inhibition of 12/15-Lipoxygenase Protects Against ?-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes. Diabetes 66:2875-2887
Fusakio, Michael E; Willy, Jeffrey A; Wang, Yongping et al. (2016) Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell 27:1536-51
McKenney-Drake, Mikaela L; Rodenbeck, Stacey D; Owen, Meredith K et al. (2016) Biphasic alterations in coronary smooth muscle Ca(2+) regulation in a repeat cross-sectional study of coronary artery disease severity in metabolic syndrome. Atherosclerosis 249:1-9
McKenney-Drake, Mikaela L; Rodenbeck, Stacey D; Owen, Meredith K et al. (2016) Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine. Data Brief 7:1393-5
Ye, Lihua; Robertson, Morgan A; Mastracci, Teresa L et al. (2016) An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration. Dev Biol 409:354-69
Lakhter, Alexander J; Sims, Emily K (2015) Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders. Mol Endocrinol 29:1535-48
Wilson, Gabriel J; Lennox, Brittany A; She, Pengxiang et al. (2015) GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab 308:E283-93

Showing the most recent 10 out of 52 publications