The average American undergoes nine surgical or interventional procedures over their lifetime, many related to diseases of the digestive track or conditions associated with obesity. Despite being common, most of these procedures have not been subjected to rigorous evaluation of their effectiveness. In addition, the best practices needed to accomplish the best outcomes, population-level results, patient-reported perspectives, and cost considerations have yet to be addressed. As healthcare systems strive to deliver greater value and increase the effectiveness of the care they deliver, addressing these gaps is critical. One reason for the shortfall in rigorous clinical research in gastrointestinal conditions commonly treated with surgery is a paucity of formal training in health services, clinical trials, and comparative effectiveness research for surgeons. To address this need, we propose the continuation of the University of Washington's T32 fellowship in clinical, health services, and comparative effectiveness research for surgeons. This fellowship involves didactic training and practical experience in advanced clinical research methodology focused on interventions related to the gastrointestinal system, diabetes, and obesity-related conditions. The training is focused in 6 areas (research using observational data, patient-centered outcome and preference assessment, health economics and behavioral economics in healthcare, implementation and health system science, clinical trials, and research operations management) and is intended to develop surgeon-scholars who will be successful scientists and leaders in academic medicine. The didactic component includes coursework that results in a Master of Public Health or Master of Science degree. Trainees complete a set of projects and studies using the full spectrum of research methods and approaches. The trainee's experience is fostered by a structured mentorship program, led by investigators who have a career commitment to training and demonstrated success in high-level research and integrating evidence into practice. Many of the projects led by fellows involve collaboration with a unique, statewide data sharing network of 45 hospitals and a national research platform of over 40 hospitals in 15 states. These networks allow for observational cohort studies and support the conduct of randomized trials in the management of common gastrointestinal conditions (e.g., appendicitis and diverticulitis). Trainees participate in the fellowship for two years and then serve an additional 3-5 years of clinical training. Past and current fellows have had high levels of research success judged by publications and presentations, and the program has had a considerable impact on trainees, the community, and the nation. Prior trainees who have completed their clinical training are now taking academic positions and have been finding success as independent investigators. The significant changes planned for the training in this cycle include a greater focus on clinical trials and learning health systems research related to gastrointestinal conditions. This emphasis parallels the increased number of funded RCTs and health system science studies being led by the mentors.

Public Health Relevance

Surgeons need formalized, rigorous training programs to prepare them to conduct the type of research that is needed for a more effective and efficient healthcare delivery system. This T32 training program prepares surgeons for successful careers in research and in leading the learning healthcare systems of the future, with a focus on gastrointestinal conditions that are some of the most common reasons for surgery. With rigorous training in research methods, practical skills for leading research centers, statewide and national platforms for community-based research, and structured mentorship, these trainees will become independently funded scientists and leaders in high-impact surgical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK070555-11
Application #
9934819
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Densmore, Christine L
Project Start
2010-07-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
11
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Washington
Department
Surgery
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Thornblade, Lucas W; Flum, David R; Flaxman, Abraham D (2018) Predicting Future Elective Colon Resection for Diverticulitis Using Patterns of Health Care Utilization. EGEMS (Wash DC) 6:1
Thornblade, Lucas W; Arbabi, Saman; Flum, David R et al. (2018) Facility-Level Factors and Outcomes After Skilled Nursing Facility Admission for Trauma and Surgical Patients. J Am Med Dir Assoc 19:70-76.e1
Thornblade, Lucas W; Seo, Yongwoo D; Kwan, Tracy et al. (2018) Enhanced Recovery via Peripheral Nerve Block for Open Hepatectomy. J Gastrointest Surg 22:981-988
Ehlers, Anne P; Davidson, Giana H; Deeney, Kimberly et al. (2017) Methods for Incorporating Stakeholder Engagement into Clinical Trial Design. EGEMS (Wash DC) 5:4
Verdial, Francys C; Etzioni, Ruth; Duggan, Catherine et al. (2017) Demographic changes in breast cancer incidence, stage at diagnosis and age associated with population-based mammographic screening. J Surg Oncol 115:517-522
Comparative Effectiveness Research Translation Network's Collaborative for Healthcare Research in Behavioral Economics and Decision Sciences (CERTAIN-CHOICES) (2017) Factors influencing delayed hospital presentation in patients with appendicitis: the APPE survey. J Surg Res 207:123-130
Ehlers, Anne P; Oelschlager, Brant K; Pellegrini, Carlos A et al. (2017) Achalasia Treatment, Outcomes, Utilization, and Costs: A Population-Based Study from the United States. J Am Coll Surg 225:380-386
Ehlers, Anne P; Roy, Senjuti Basu; Khor, Sara et al. (2017) Improved Risk Prediction Following Surgery Using Machine Learning Algorithms. EGEMS (Wash DC) 5:3
Davidson, Giana H; Austin, Elizabeth; Thornblade, Lucas et al. (2017) Improving transitions of care across the spectrum of healthcare delivery: A multidisciplinary approach to understanding variability in outcomes across hospitals and skilled nursing facilities. Am J Surg 213:910-914
Thornblade, Lucas W; Cheng, Aaron M; Wood, Douglas E et al. (2017) A Nationwide Rise in the Use of Stents for Benign Esophageal Perforation. Ann Thorac Surg 104:227-233

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