The current explosion in obesity, insulin resistance and diabetes, and their diverse complications underscores the urgent need to increase the cadre of well-trained investigators in the area of metabolism. The Interdisciplinary Training Program in Metabolism at the University of Utah is new training program, designed to provide post-doctoral training to physician scientists and PhD scientists and to provide training to pre-doctoral MD PhD, and PhD candidates in the area of metabolism. We are seeking support for 3 post-doctoral positions and 2-predoctoral positions. There is a dearth of training opportunities in metabolic disease in the intermountain west, and as such this program will meet a critical need. The training program is designed to stimulate scientific interactions and collaborations in an interdisciplinary environment with basic and clinical researchers at various career stages. The program builds on unique strengths in metabolism research at the University of Utah that spans basic and mechanistic investigation across a range of model organisms to translational studies in humans. The training program is built upon on strong mentor-based training in basic and clinical investigation and a rigorous didactic curriculum including a core curriculum in metabolism as well as specific training in research methodologies and grant writing. Trainees will receive tailored career mentoring to ensure a successful transition to the next stage of their career. The training faculty comprises 18 highly interactive faculty, with strong collaborations, stable extramural funding and dynamic research programs, who are members of the Metabolism Interest Group, which spans five departments within the School of Medicine, and four divisions within the Department of Internal Medicine. The broad reach of the Metabolism Interest Group will guarantee reliable recruitment of suitable trainees. Clinically qualified trainees will be recruited from fellowship training programs in Endocrinology, Cardiology, Gastroenterology and Nephrology and PhD post-docs will be recruited nationally. Pre-doctoral candidates will be recruited from the combined programs in Biological Chemistry and Molecular Biology at the University of Utah. The training program is integrated with training activities of the Molecular Medicine Program, the Center for Clinical and Translational Science and the graduate programs in Molecular Biology and Biological Chemistry. The training program will be administered through the Division of Endocrinology Metabolism and Diabetes, and will be overseen by an executive committee comprising the Principal Investigator and 3 co-directors, all of whom are senior investigators with strong track records of and uncompromising commitment to mentoring trainees.

Public Health Relevance

The Interdisciplinary Training Program in Metabolism is designed to provide training in metabolism to 2 pre- doctoral and 3 post-doctoral trainees. The training program draws upon the expertise of 18 faculty mentors who are members of the Metabolism Interest Group. This diverse, interactive and multidisciplinary group draws upon faculty from six departments within the School of Medicine of the University of Utah. The group is focused on basic and clinical studies that will investigate the mechanisms that underlie diverse metabolic disorders such as obesity, diabetes, insulin resistance and their complications. This training program will fill a critical need to increase the cadre of trained investigators who are tackling the growing epidemic of obesity-related metabolic disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK091317-03
Application #
8490368
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$197,641
Indirect Cost
$16,408
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Vázquez-Arreguín, Karina; Maddox, Jessica; Kang, Jinsuk et al. (2018) BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Mol Cancer Res 16:439-452
Nielson, Jason R; Rutter, Jared P (2018) Lipid-mediated signals that regulate mitochondrial biology. J Biol Chem 293:7517-7521
Karanth, Santhosh; Adams, J D; Serrano, Maria de Los Angeles et al. (2018) A Hepatocyte FOXN3-? Cell Glucagon Axis Regulates Fasting Glucose. Cell Rep 24:312-319
Fidler, Trevor P; Rowley, Jesse W; Araujo, Claudia et al. (2017) Superoxide Dismutase 2 is dispensable for platelet function. Thromb Haemost 117:1859-1867
Reno, Candace M; VanderWeele, Jennifer; Bayles, Justin et al. (2017) Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. Diabetes 66:3091-3097
Simcox, Judith; Geoghegan, Gisela; Maschek, John Alan et al. (2017) Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metab 26:509-522.e6
Palu, Rebecca A S; Praggastis, Sophia A; Thummel, Carl S (2017) Parental obesity leads to metabolic changes in the F2 generation in Drosophila. Mol Metab 6:631-639
Fidler, Trevor P; Middleton, Elizabeth A; Rowley, Jesse W et al. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol 37:1628-1639
Reno, Candace M; Puente, Erwin C; Sheng, Zhenyu et al. (2017) Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes 66:587-597
Praggastis, Sophia A; Thummel, Carl S (2017) Right time, right place: the temporal regulation of developmental gene expression. Genes Dev 31:847-848

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