The Department of Radiology at the University of Pennsylvania proposes continuation of its innovative T32- spomsored Research Track Radiology Residency Program with the goal of developing imaging clinician- scientists. The clinical and scientific importance of biomedical imaging, rapid progress in imaging technology, and an increasing investment in imaging research create an ongoing and increasing need for imaging-based clinician scientists to assure translation of these advances into human research and clinical practice. There continues to be a talented pool of resident applicants to academic radiology residency programs across the US but only a small fraction of programs equipped to fully train radiology clinician-investigators. The training program described for this proposal continues the Penn radiology residency track designed for trainees interested in careers as imaging scientists, leveraging a highly active program in imaging and image-guided therapy and the large and well-developed research infrastructure within Penn's Radiology Department. The Program specifically includes 1 year of research training during the 4th year of radiology residency and a second optional research fellowship year undertaken in the context of an integrated radiology resident experience that meets the requirement for board certification. In this renewal proposal, we continue to emphasize the development and application of technology for biomedical imaging and image-guided therapy apropos to NIBIB training priorities. We leverage the considerable success of our prior and current trainees in obtaining academic radiology faculty positions, publishing high-impact research papers, and developing independent research programs and funding, including the first 2 NIH Early Independence Awards ever given to investigators primarily appointed in a radiology department. Other accomplishments include successful integration of the research preceptorship year and research undertaken during subsequent fellowship specialty training in order to assure continuity. Proposed Program innovations for this renewal include (1) a dedicated spot for Interventional Radiology spurred by increasing research in the field and new training pathways; (2) increased focus on rapidly advancing areas of imaging research ? molecular imaging, imaging analytics/informatics, and image-guide therapy ? with new faculty mentors in these areas; and (3) further integration of post-residency fellowship training and research to assure continuity from the Program's dedicated research preceptorship. In summary, we request to continue our highly successful program to train imaging and image-guided therapy focused clinician-scientists.

Public Health Relevance

Health-relatedness statement This program proposes continuing the Research Track Radiology Residency Program, which incorporates research training into the clinical radiology residency. This will produce clinician-scientists who can perform high-quality imaging research that is relevant and translatable to patient care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
2T32EB004311-16
Application #
9933668
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Erim, Zeynep
Project Start
2005-05-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
16
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Elmi, Azadeh; McDonald, Elizabeth S; Mankoff, David (2018) Imaging Tumor Proliferation in Breast Cancer: Current Update on Predictive Imaging Biomarkers. PET Clin 13:445-457
Derakhshan, Jamal J; McDonald, Elizabeth S; Siegelman, Evan S et al. (2018) Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: Chemical shift artifact of the third kind. Magn Reson Med 79:2277-2289
Sellmyer, Mark A; Lee, Iljung; Hou, Catherine et al. (2017) Quantitative PET Reporter Gene Imaging with [11C]Trimethoprim. Mol Ther 25:120-126
Pantel, Austin R; Mankoff, David A (2017) Molecular imaging to guide systemic cancer therapy: Illustrative examples of PET imaging cancer biomarkers. Cancer Lett 387:25-31
Zhou, Rong; Pantel, Austin R; Li, Shihong et al. (2017) [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res 77:1476-1484
Sellmyer, Mark A; Lee, Iljung; Hou, Catherine et al. (2017) Bacterial infection imaging with [18F]fluoropropyl-trimethoprim. Proc Natl Acad Sci U S A 114:8372-8377
Mankoff, David A; Edmonds, Christine E; Farwell, Michael D et al. (2016) Development of Companion Diagnostics. Semin Nucl Med 46:47-56
Schmitt, J Eric; Yi, James; Calkins, Monica E et al. (2016) Disrupted anatomic networks in the 22q11.2 deletion syndrome. Neuroimage Clin 12:420-8
Weber, Charles N; Lev-Toaff, Anna S; Levine, Marc S et al. (2016) Impact of hysterectomy on three-dimensional rectosigmoid morphology and endoscopy performance: a pilot study. Abdom Radiol (NY) 41:311-6
Edmonds, Christine E; Makvandi, Mehran; Lieberman, Brian P et al. (2016) [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. Am J Nucl Med Mol Imaging 6:94-101

Showing the most recent 10 out of 21 publications