Abstract

The goal of this training program is to generate scientists who can help in the fight to prevent congenital malformations, especially those birth defects induced epigenetically, by agents in our environment. The approach taken to try and reach this goal has been to view congenital malformations as molecular perturbations of developmental pathways. Thus, academically, the students encounter a heavy class load related to molecular biology and molecular genetics. This educational focus on molecular biology is carried on throughout the training program including seminar and journal clubs, and especially in laboratory experiences. The application requests support for four predoctoral students and three postdoctoral fellows. The majority of trainees will work in the Children's Hospital Research Foundation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007051-23
Application #
2872281
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
23
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Chapman, Heather; Riesenberg, Amy; Ehrman, Lisa A et al. (2018) Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence. Dev Biol 442:115-126
Sprowles, Jenna L N; Amos-Kroohs, Robyn M; Braun, Amanda A et al. (2018) Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats. Neurotoxicol Teratol 67:50-64
Gutierrez, Arnold; Williams, Michael T; Vorhees, Charles V (2018) A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats. Neurotox Res 33:671-680
Millington, Grethel; Elliott, Kelsey H; Chang, Ya-Ting et al. (2017) Cilia-dependent GLI processing in neural crest cells is required for tongue development. Dev Biol 424:124-137
Stottmann, Rolf W; Driver, Ashley; Gutierrez, Arnold et al. (2017) A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization. Genes Brain Behav 16:250-259
Hufgard, J R; Williams, M T; Vorhees, C V (2017) Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice. Genes Brain Behav 16:756-767
Jablonski, Sarah A; Graham, Devon L; Vorhees, Charles V et al. (2017) Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats. Neurotox Res 31:269-282
Amos-Kroohs, Robyn M; Davenport, Laurie L; Atanasova, Nina et al. (2017) Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory. Neurotoxicol Teratol 59:16-26
Jablonski, Sarah A; Williams, Michael T; Vorhees, Charles V (2017) Learning and memory effects of neonatal methamphetamine exposure in rats: Role of reactive oxygen species and age at assessment. Synapse 71:
Gutierrez, Arnold; Jablonski, Sarah A; Amos-Kroohs, Robyn M et al. (2017) Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory. ACS Chem Neurosci 8:1479-1489

Showing the most recent 10 out of 151 publications