Abstract

This is a request for continuing support for predoctoral and postdoctoral trainees in 4 broad areas of toxicology; cellular and molecular toxicology, carcinogenesis, neurotoxicology, and pulmonary toxicology. The objective of this training program is to provide a strong grounding in the principles of toxicology followed by specific expertise in one specific area. The intent is to produce trainees capable of conducting meaningful research in their field but also able to communicate with investigators in other sciences and fields of toxicology. For doctoral trainees this is achieved through formal didactic sessions followed by extensive laboratory work in a specific field of research. The formal didactic training consists of 33 hours of core course work, 3 elective courses, and 13 hours of focused research in 1 or 2 laboratories. Students have a comprehensive written examination at completion of course work, and both preliminary and oral examinations on their individual research proposal and dissertation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007126-18
Application #
2872290
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1982-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
18
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Buglak, Nicholas E; Jiang, Wulin; Bahnson, Edward S M (2018) Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats. Redox Biol 19:166-178
Mosedale, Merrie; Eaddy, J Scott; Trask Jr, O Joseph et al. (2018) miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model. Toxicol Sci 161:149-158
Dover, E Nicole; Patel, Naishal Y; Stýblo, Miroslav (2018) Impact of in vitro heavy metal exposure on pancreatic ?-cell function. Toxicol Lett 299:137-144
Huang, Madelyn C; Douillet, Christelle; Dover, Ellen N et al. (2018) Prenatal arsenic exposure and dietary folate and methylcobalamin supplementation alter the metabolic phenotype of C57BL/6J mice in a sex-specific manner. Arch Toxicol 92:1925-1937
Hazari, Mehdi S; Stratford, Kimberly M; Krantz, Q Todd et al. (2018) Comparative Cardiopulmonary Effects of Particulate Matter- And Ozone-Enhanced Smog Atmospheres in Mice. Environ Sci Technol 52:3071-3080
Stratford, Kimberly; Haykal-Coates, Najwa; Thompson, Leslie et al. (2018) Early-Life Persistent Vitamin D Deficiency Alters Cardiopulmonary Responses to Particulate Matter-Enhanced Atmospheric Smog in Adult Mice. Environ Sci Technol 52:3054-3061
Jefferson, Wendy N; Kinyamu, H Karimi; Wang, Tianyuan et al. (2018) Widespread enhancer activation via ER? mediates estrogen response in vivo during uterine development. Nucleic Acids Res 46:5487-5503
Buglak, Nicholas E; Batrakova, Elena V; Mota, Roberto et al. (2018) Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxid Med Cell Longev 2018:2468457
Dover, E N; Beck, R; Huang, M C et al. (2018) Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 ? cells. Arch Toxicol 92:693-704
Burbank, Allison J; Duran, Charity G; Pan, Yinghao et al. (2018) Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol 141:1231-1238.e1

Showing the most recent 10 out of 455 publications