The NIEHS Training Program in Environmental Health Sciences is in its thirtieth year and has supported 57 current and former pre-doctoral and 26 current and former postdoctoral trainees since 2003. Thirty-seven former pre-doctoral and twenty-one former postdoctoral trainees are in career positions in the private sector/industry, government or academia. There are currently 15 pre-doctoral and 7 postdoctoral trainees. Combined, current and former trainees have published over 280 peer-reviewed papers and book chapters. The need for this Training Program arises directly from the vision statement for the NIEHS that is being refined in the new 2012 Strategic Plan to ... """"""""provide global leadership for innovative research that improves public health by preventing disability and disease from our environment"""""""". At the core for the implementation of this vision is the need to """"""""recruit and train the next generation of environmental health scientists"""""""". The Johns Hopkins Training Program is uniquely situated to make important contributions to the national efforts of NIEHS to achieve this vision by being anchored within the large, multidisciplinary Hopkins School of Public Health. In this renewal application, based on the foci of research of the training faculty, the investigators have framed the Training Program into three areas: Molecular Mechanisms of Toxicity;Environmental Epidemiology/Exposure Sciences and Translational Toxicology. Within these three broad areas, the research being conducted by the faculty together with their pre- and postdoctoral trainees addresses one or more of the following topics: a) Mechanisms of disease pathobiology;b) Development and application of biomarkers of the pathobiology (e.g. biomarkers of response, effect, susceptibility);c) Development of prevention intervention and translational strategies;and, d) Environmental disease epidemiology. Within these areas, the research addresses a number of diseases to which environmental exposures contribute including cancer, COPD, asthma, CVD and neurodegenerative diseases. The Program is both interdisciplinary and interdepartmental. Training faculty members involved in the current application are from the Departments of Environmental Health Sciences (EHS), Biochemistry and Molecular Biology, in the School of Public Health and from the School of Medicine's Departments of Oncology and Comparative Medicine. All hold primary or joint appointments in EHS. In this renewal application the investigators are requesting 15 pre-doctoral positions and 4 postdoctoral positions.

Public Health Relevance

The Training Program is directly relevant to the health burden of environmental exposures on people living in the U.S. and throughout the world. The mission of this Training Program is to provide the academic and research foundation for graduate and post-graduate scientists to become future leaders of interdisciplinary research projects that seek to understand the role that environmental exposures play in the etiology and exacerbation of human disease and apply this knowledge to develop prevention and intervention strategies. The Program prepares trainees to be the next generation of environmental health researchers who will set and address the nation's environmental health research agenda with the goal of reducing incidence, morbidity, recurrence, and mortality, and the disparities in diseases including cancer, COPD, cardiovascular disease and neurological disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
2T32ES007141-31A1
Application #
8666243
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1983-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129
Gour, Naina; Lajoie, Stephane; Smole, Ursula et al. (2018) Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. Sci Immunol 3:
Balakrishnan, Poojitha; Jones, Miranda R; Vaidya, Dhananjay et al. (2018) Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Int J Environ Res Public Health 15:
Spratlen, Miranda J; Grau-Perez, Maria; Best, Lyle G et al. (2018) The Association of Arsenic Exposure and Arsenic Metabolism with the Metabolic Syndrome and its Individual Components: Prospective Evidence from the Strong Heart Family Study. Am J Epidemiol :
Davis, Meghan F; Pisanic, Nora; Rhodes, Sarah M et al. (2018) Occurrence of Staphylococcus aureus in swine and swine workplace environments on industrial and antibiotic-free hog operations in North Carolina, USA: A One Health pilot study. Environ Res 163:88-96
Luechtefeld, Thomas; Rowlands, Craig; Hartung, Thomas (2018) Big-data and machine learning to revamp computational toxicology and its use in risk assessment. Toxicol Res (Camb) 7:732-744
Gour, Naina; Smole, Ursula; Yong, Hwan-Mee et al. (2018) C3a is required for ILC2 function in allergic airway inflammation. Mucosal Immunol 11:1653-1662
Poulsen, Melissa N; Pollak, Jonathan; Sills, Deborah L et al. (2018) Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. Int J Hyg Environ Health 221:323-333
Gour, Naina; Sudini, Kuladeep; Khalil, Syed Muaz et al. (2018) Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash. Environ Res 161:304-313
Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740

Showing the most recent 10 out of 230 publications