This is a competitive renewal application for the Training Program in Environmental Health Sciences that is based at the Harvard School of Public Health. This is an interdisciplinary and interdepartmental program that currently supports 12 predoctoral and 3 postdoctoral trainees. Twenty-three Harvard University faculty members are listed as preceptors; most of these are in the Biology in Public Health (BPH) program at the Harvard School of Public Health (HSPH) and are members of the HSPH NIEHS Center for Environmental Health (an interdisciplinary unit that fosters research and administers the NIEHS Center Grant ES000002); the remaining preceptors are in the Biological and Biomedical Sciences (BBS) program in the Harvard Medical area. The faculty preceptors are located in the following departments: Cancer Cell Biology, Environmental Health, Nutrition, Epidemiology, immunology and Infectious Disease, Chemistry and Molecular Pharmacology, Microbiology and Molecular Genetics, and Pathology. The home base of this training program is the School of Public Health where there is a strong emphasis on the application of knowledge gained through basic research to the protection of human health from the effects of toxic environmental agents. Its strength derives from this fact as well as the fact that the training faculty has a broad range of skills ranging from structure/function analyses of environmentally relevant macromolecules (e.g., DNA repair and recombination proteins), to molecular epidemiological studies of human gene-environment interactions, to assessments of real-life exposures of human populations to environmental pollutants. The investigators continue to offer an array of basic studies on how bacteria, yeast, cultured mammalian cells, knockout and transgenic mice, and humans respond to environmental agents with emphasis on how the agents are perceived, how signals are transduced to various parts of the cell or animal, and on the biological consequences of toxin exposure. They believe that this program offers an exciting range of research for both predoctoral and postdoctoral training. The proposed training program is also proud of the superb quality of the applicants, the participating departments and the laboratories of individual preceptors. A rigorous training is proposed for both predoctoral and postdoctoral trainees, and it is expected that this training will position the trainees for productive careers in the Environmental Health Sciences in academia, government, etc.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007155-21
Application #
6917294
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1985-07-01
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
21
Fiscal Year
2005
Total Cost
$557,743
Indirect Cost
Name
Harvard University
Department
Genetics
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Birmann, Brenda M; Barnard, Mollie E; Bertrand, Kimberly A et al. (2016) Nurses' Health Study Contributions on the Epidemiology of Less Common Cancers: Endometrial, Ovarian, Pancreatic, and Hematologic. Am J Public Health 106:1608-15
Eum, Ki-Do; Wang, Florence T; Schwartz, Joel et al. (2013) Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function. Neurotoxicology 39:65-71
Wu, Hongyu; Bertrand, Kimberly A; Choi, Anna L et al. (2013) Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis. Environ Health Perspect 121:153-61
Cao, Haiming; Sekiya, Motohiro; Ertunc, Meric Erikci et al. (2013) Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab 17:768-78
Gregor, Margaret F; Misch, Emily S; Yang, Ling et al. (2013) The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep 3:1430-9
Fu, Suneng; Fan, Jason; Blanco, Joshua et al. (2012) Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet 8:e1002902
Bertrand, Kimberly A; Giovannucci, Edward; Liu, Yan et al. (2012) Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts. Br J Nutr 108:1889-96
Zwack, Leonard M; Paciorek, Christopher J; Spengler, John D et al. (2011) Modeling spatial patterns of traffic-related air pollutants in complex urban terrain. Environ Health Perspect 119:852-9
Bertrand, Kimberly A; Chang, Ellen T; Abel, Gregory A et al. (2011) Sunlight exposure, vitamin D, and risk of non-Hodgkin lymphoma in the Nurses' Health Study. Cancer Causes Control 22:1731-41
Liu, Sihao; Hatano, Ben; Zhao, Minghui et al. (2011) Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem 286:1237-47

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