The Multidisciplinary Training Program in Environmental Toxicology (MTPET) described in this application produces scientists having a base knowledge in environmental toxicology coupled with research expertise gained in a departmentally-based, biomedical science graduate program. Predoctoral trainees must meet the full Ph.D. requirements of their """"""""home"""""""" department and complete the coursework, research and interactive aspects of the MTPET administered through the Institute for Environmental Toxicology (lET). The degree awarded recognizes the dual nature of the training by listing the department-environmental toxicology (e.g., Ph.D. in """"""""Biochemistry and Molecular Biology- Environmental Toxicology""""""""). Graduates of the program are well equipped to conduct research and interact with other scientists in the course of solving complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Fifteen training faculty conduct predoctoral training in five departmental Ph. D. programs (Pharmacology and Toxicology, Biochemistry and Molecular Biology, Food Science and Human Nutrition, Zoology, Cell and Molecular Biology). Added to the department-based education and environmental toxicology research training in participating departments are didactic, toxicology-oriented courses and other requirements of the MTPET. This coursework and less formal multidisciplinary interactions and activities provided by the lET and MTPET impart a wider scope of knowledge than is available within individual departmental programs. Research topics for trainees are available in mechanisms-related toxicology encompassing various organ systems (e.g., hepatic, immune, endocrine, neuronal, respiratory), carcinogenesis, and food safety. There is an integrative biology emphasis to the research training, which encompasses whole animal, cell-based, molecular and genomic methodologies to understand mechanisms of toxicity and factors governing susceptibility. Postdoctoral trainees conduct research in the laboratory of one (or more) of the training faculty and gain additional environmental toxicology experience through participation in lET and MTPET activities and courses. This application is for support of six predoctoral and three postdoctoral trainees, thereby continuing a highly effective multidisciplinary training program which mixes formal and informal approaches to prepare graduates to make significant contributions to the field of environmental toxicology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007255-19
Application #
7256238
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1989-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
19
Fiscal Year
2007
Total Cost
$332,097
Indirect Cost
Name
Michigan State University
Department
Type
Organized Research Units
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884
Henriquez, Joseph E; Rizzo, Michael D; Crawford, Robert B et al. (2018) Interferon-?-Mediated Activation of T Cells from Healthy and HIV-Infected Individuals Is Suppressed by ?9-Tetrahydrocannabinol. J Pharmacol Exp Ther 367:49-58
Chen, Chen; Mitchell, Nicole J; Gratz, Jean et al. (2018) Exposure to aflatoxin and fumonisin in children at risk for growth impairment in rural Tanzania. Environ Int 115:29-37
Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8
Veiga-Lopez, Almudena; Pu, Yong; Gingrich, Jeremy et al. (2018) Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps. Trends Endocrinol Metab 29:607-625
Rizzo, Michael D; Crawford, Robert B; Henriquez, Joseph E et al. (2018) HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-?-inducible protein 10 levels compared with nonusing HIV patients. AIDS 32:419-429
Henriquez, Joseph E; Rizzo, Michael D; Schulz, Matthias A et al. (2017) ?9-Tetrahydrocannabinol Suppresses Secretion of IFN? by Plasmacytoid Dendritic Cells From Healthy and HIV-Infected Individuals. J Acquir Immune Defic Syndr 75:588-596
Rockwell, Cheryl E; Turley, Alexandra E; Cheng, Xingguo et al. (2017) Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. Food Chem Toxicol 100:24-33
Bailey, Jordan M; Colón-Rodríguez, Alexandra; Atchison, William D (2017) Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1. Curr Environ Health Rep 4:200-207
Mitchell, Nicole J; Riley, Ronald T; Egner, Patricia A et al. (2017) Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study. J Expo Sci Environ Epidemiol 27:106-111

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