Abstract

This is an application for continued support of an interdisciplinary training program in environmental pathology for predoctoral, postdoctoral, and medical students. The objective of the program is to prepare trainees for careers in environmental pathology with a focus on independent research activities. Didactic courses are provided in general pathology, environmental toxicology, cancer biology, immunopathology, experimental carcinogenesis, and molecular basis of disease. Formal courses are supplemented by various enrichment activities. Strong emphasis has been placed on developing communication and presentation skills, grantsmanship, teamwork, and implications of basic research on public policy decisions. The program faculty includes 14 researchers from various departments all of which have active research programs focusing on themes germane to the training program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007272-08
Application #
2872304
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1992-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Brown University
Department
Pathology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912

  Publications

Dere, Edward; Anderson, Linnea M; Huse, Susan M et al. (2018) Effects of continuous bisphenol A exposure from early gestation on 90?day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study. Toxicol Appl Pharmacol 347:1-9
Patel, Mohak; Leggett, Susan E; Landauer, Alexander K et al. (2018) Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep 8:5581
Valentin, Thomas M; Leggett, Susan E; Chen, Po-Yen et al. (2017) Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip 17:3474-3488
Rodd, April L; Messier, Norma J; Vaslet, Charles A et al. (2017) A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144
Foster, Melanie L; Bartnikas, Thomas B; Maresca-Fichter, Hailey C et al. (2017) Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure. Data Brief 15:908-915
Dai, M S; Hall, S J; Vantangoli Policelli, M M et al. (2017) Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Andrology 5:1141-1152
Leggett, Susan E; Khoo, Amanda S; Wong, Ian Y (2017) Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci 5:1460-1479
Leggett, Susan E; Wong, Ian Y (2017) Nanomedicine: Catching tumour cells in the zone. Nat Nanotechnol 12:191-193
Francois-Vaughan, Heather; Adebayo, Adeola O; Brilliant, Kate E et al. (2016) Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma. Carcinogenesis 37:408-419
Borgas, Diana; Chambers, Eboni; Newton, Julie et al. (2016) Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol 54:683-96

Showing the most recent 10 out of 108 publications