Environmental Toxicology training at Texas A&M University is coordinated through the Interdisciplinary Faculty of Toxicology (IFT) which has faculty membership from all the major Life Sciences Departments. Preand postdoctoral trainees also participate in the multiple health science initiatives including the Center for Environmental and Rural Health (CERH), Superfund Basic Research Program (SBRP) and the Partnership for Environmental Education and Rural Health. All trainees will complete core course requirements in toxicology and satisfy IFT, departmental, and University academic requirements. Trainees will also participate in multiple enrichment activities which include: (a) participation in annual research symposia sponsored by IFT and CERH; (b) attendance at weekly [FT seminars; (c) participation at both regional (Gulf Coast) and national Society of Toxicology meetings; and (d) participation/attendance at other local, regional and national scientific conferences. Special emphasis on minority recruitment will continue to be an important objective of this grant. The proposed training program will provide a challenging research program focused on diverse areas of environmental toxicology that will be directed by ten co-investigators. Research programs of training faculty include: fluorescent/imaging analysis of toxicant and hormonally-induced injury (Burghardt); bioassay-directed analysis of endocrine-active chemicals and marine mammal genetics (Busbee); risk assessment and genotoxic mechanisms of PAH mixtures (Donnelly); gene-environment interactions and their modulation of embryonic development (Finnell); male reproduction and spermatogenesis (Johnson); development of clay-based technologies for toxicant-specific adsorption (Phillips); genetic and epigenetic modulation of vascular and renal cell proliferation and differentiation (Ramos); mechanisms of estrogen receptor-mediated gene expression and inhibitory Ah receptor crosstalk in breast cancer (Safe); mechanisms of heavy metal-induced neurotoxicity in cell culture and in vivo (Tiffany- Castiglioni); mechanisms and applications of organophosphorus degrading genes (Wild). The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007273-12
Application #
6614439
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1992-07-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
12
Fiscal Year
2003
Total Cost
$273,437
Indirect Cost
Name
Texas A&M University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
078592789
City
College Station
State
TX
Country
United States
Zip Code
77845
Barhoumi, Rola; Mouneimne, Youssef; Ramos, Ernesto et al. (2011) Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56
Wellberg, Elizabeth; Metz, Richard P; Parker, Caitlin et al. (2010) The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. Development 137:945-52
Barhoumi, Rola; Qian, Yongchang; Burghardt, Robert C et al. (2010) Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges. Neurotoxicol Teratol 32:16-24
Barhoumi, Rola; Catania, Jeffrey M; Parrish, Alan R et al. (2009) Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. J Toxicol Sci 34:13-25
Martinez, Josue G; Huang, Jianhua Z; Burghardt, Robert C et al. (2009) USE OF MULTIPLE SINGULAR VALUE DECOMPOSITIONS TO ANALYZE COMPLEX INTRACELLULAR CALCIUM ION SIGNALS. Ann Appl Stat 3:1467-1492
Cho, Taehyeon M; Wild, James R; Donnelly, Kirby C et al. (2006) Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A 69:1413-29
Yang, Wonsuk; Tiffany-Castiglioni, Evelyn (2005) The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. J Toxicol Environ Health A 68:1939-61
Miller, Kimberly P; Ramos, Kenneth S (2005) DNA sequence determinants of nuclear protein binding to the c-Ha-ras antioxidant/electrophile response element in vascular smooth muscle cells: identification of Nrf2 and heat shock protein 90beta as heterocomplex components. Cell Stress Chaperones 10:114-25
Cizmas, Leslie; McDonald, Thomas J; Phillips, Tracie D et al. (2004) Toxicity characterization of complex mixtures using biological and chemical analysis in preparation for assessment of mixture similarity. Environ Sci Technol 38:5127-33
Cizmas, Leslie; Zhou, Guo-dong; Safe, Stephen H et al. (2004) Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions. Environ Mol Mutagen 43:159-68

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