This is a competing continuation application to renew the Research Training Program in Environmental Toxicology. Established in 2000 to help recruit new scientists into this important discipline, the Program educates pre- and postdoctoral trainees in reproductive, developmental and endocrine toxicology. The need to train students and postdoctoral fellows in these aspects of toxicology is every bit as urgent today as it was 10 years ago when the training program was first conceived. Environmental chemicals that act as endocrine disrupters continue to dominate environmental health concerns. The program unites two long recognized areas of research excellence on the University of Illinois campus, environmental toxicology and reproductive biology, and the investigators can count among their preceptors some of the brightest stars on the University of Illinois campus. Several outstanding new preceptors have joined the Program since the last submission (Flaws, Hofmann) and two additional preceptors are added in this renewal application (Boppart, Freund) resulting in a total of 15 preceptors from seven departments (Animal Sciences, Bioengineering, Chemistry, Crop Sciences, Food Science and Human Nutrition, Molecular and Integrative Physiology and Veterinary Biosciences). Together these faculty currently have over 40 federally funded research grants totaling more than $9 million dollars per year direct costs. The preceptors are researching endocrine active chemicals using a broad multidisciplinary perspective. Collaborations among laboratories working at the molecular, cellular, whole animal and human health levels provide trainees with the unique opportunity to directly observe and participate in translational research. Selection of trainees is based on academic success, relevance of proposed research to Program goals and commitment to toxicology. Preference is given to pre-doctoral trainees in their first or second year of graduate study. The Program offers a broad range of graduate level courses in toxicology. In addition to their departmental requirements, all pre-doctoral trainees take basic toxicology, systems toxicology and at least one other advanced toxicology course related to their field of study. Postdoctoral trainees conduct independent research in toxicology. All trainees are required to attend weekly toxicology research seminars, career development workshops, a toxicology journal club and a course on research ethics in toxicology. Trainees are also required to present their research in the seminar and strongly encouraged to present their research at national meetings. The investigators have a strong record of recruiting and retaining qualified students from underrepresented groups and we will continue and expand these efforts. Relevance: This Training Program will train pre- and postdoctoral students to become the next generation of research scientists in endocrine, developmental and reproductive toxicology, subdisciplines of toxicology that are directly relevant to human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007326-13
Application #
8296294
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
2000-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
13
Fiscal Year
2012
Total Cost
$288,226
Indirect Cost
$20,904
Name
University of Illinois Urbana-Champaign
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Warner, Genoa R; Flaws, Jodi A (2018) Bisphenol A and Phthalates: How Environmental Chemicals Are Reshaping Toxicology. Toxicol Sci 166:246-249
Biehl, Matthew J; Kaylan, Kerim B; Thompson, Robert J et al. (2018) Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling. Dev Biol 442:87-100
Kougias, Daniel G; Cortes, Laura R; Moody, Laura et al. (2018) Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play. Endocrinology 159:1088-1105
Brehm, Emily; Rattan, Saniya; Gao, Liying et al. (2018) Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 159:795-809
Rattan, Saniya; Brehm, Emily; Gao, Liying et al. (2018) Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice. Biol Reprod 98:130-145
Hekman, Jessica P; Johnson, Jennifer L; Edwards, Whitney et al. (2018) Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes. G3 (Bethesda) 8:859-873
Kougias, Daniel G; Sellinger, Elli P; Willing, Jari et al. (2018) Perinatal exposure to an environmentally relevant mixture of phthalates results in a lower number of neurons and synapses in the medial prefrontal cortex and decreased cognitive flexibility in adult male and female rats. J Neurosci :
Eckstrum, Kirsten S; Edwards, Whitney; Banerjee, Annesha et al. (2018) Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development. Endocrinology 159:119-131
Juraska, Janice M; Willing, Jari (2017) Pubertal onset as a critical transition for neural development and cognition. Brain Res 1654:87-94
Barakat, Radwa; Lin, Po-Ching Patrick; Rattan, Saniya et al. (2017) Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice. Toxicol Sci 156:96-108

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