This proposal describes an environmental health sciences predoctoral training program at the University of Louisville. It is a dynamic partnership between the Departments of Biochemistry & Molecular Biology and Pharmacology & Toxicology, both of which have long-standing successful graduate programs. The training program benefits from their combined faculty, research, and programmatic strengths. The state-of-the art training program is enhanced through active participation and interaction with six interdisciplinary research centers: 1) Center for Environmental and Occupational Health Sciences 2) Center for Genetics and Molecular Medicine, and 3) Institute for Public Health Research, 4) Birth Defects Center, 5) James Graham Brown Cancer Center, and 6) Institute for Bioethics, Health Policy and Law. Trainees rotate through faculty laboratories to receive interdisciplinary research training and to select dissertation research projects focusing in four areas of environmental health science research: 1) environmental genomics, 2) basic mechanisms of environmental insult, 3) reproductive health and 4) environmental cardiology. A core curriculum provides an interdisciplinary academic foundation in biochemistry and molecular biology, pharmacology and toxicology, cell biology, genetics, epidemiology, biostatistics, research methods and bioethics. Initially student recruitment and funding for predoctoral trainees is provided by the University of Louisville School of Medicine Integrated Programs in the Biomedical Sciences recruitment gateway. Funds are requested to support two predoctoral trainees/year beginning in their second year. The training program will begin with four trainees and increase to eight trainees as the program matures. Several interdisciplinary program projects and core facilities also strengthen student training. The University of Louisville has increased its commitment to health science research and infrastructure, graduate education, and minority recruitment, making this training program particularly timely.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES011564-02
Application #
6916408
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$140,279
Indirect Cost
Name
University of Louisville
Department
Pharmacology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Poole, Lauren G; Beier, Juliane I; Torres-Gonzales, Edilson et al. (2018) Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung. Alcohol :
Stepp, Marcus W; Doll, Mark A; Carlisle, Samantha M et al. (2018) Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231. Mol Carcinog 57:549-558
Liang, Yaqin; Lang, Anna L; Zhang, Jian et al. (2018) Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 31:482-493
Lang, Anna L; Chen, Liya; Poff, Gavin D et al. (2018) Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatol Commun 2:270-284
Carlisle, Samantha M; Trainor, Patrick J; Doll, Mark A et al. (2018) Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity. Mol Carcinog 57:1458-1466
Lang, Anna L; Beier, Juliane I (2018) Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem 399:1237-1248
Zhang, Xiaoyan; Carlisle, Samantha M; Doll, Mark A et al. (2018) High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5?-androstane-3?,17?-Diol, or Dihydrotestosterone in Breast Cancer Cells. J Pharmacol Exp Ther 365:84-93
Hudson, Shanice V; Dolin, Christine E; Poole, Lauren G et al. (2017) Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Sci Rep 7:12444
Massey, Veronica L; Dolin, Christine E; Poole, Lauren G et al. (2017) The hepatic ""matrisome"" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice. Hepatology 65:969-982
Poole, Lauren G; Massey, Veronica L; Siow, Deanna L et al. (2017) Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol 57:315-323

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