The Interdisciplinary Training in Genes and the Environment program at the Harvard School of Public Health (HSPH) meets the critical need for well-trained scientists who have an understanding of, and commitment to, cutting-edge research at the intersection of molecular and environmental exposure biology with strong training in statistical and computational methods. The Training Program is based on active participation by 19 accomplished and experienced multidisciplinary faculty members, including environmental health scientists, molecular biologists, molecular epidemiologists, and computational biologists. The two interrelated goals of the proposed Training Program are: * To train true collaborative partners able to pursue methodological research that is motivated by, and helps to solve, difficult analytic issues that arise in studies of human environmental exposures and genetic susceptibility to complex diseases. * To encourage interdisciplinary research, especially in genetics and the various omics arising from new methodologies for characterizing biological activity associated with environmental exposures in laboratory and population sciences. Pre-doctoral students will obtain the Ph.D. in Biological Sciences in Public Health (BPH), the public health doctoral program ranked first in the nation in the recent NRC analysis. The Ph.D. degree is awarded through the Graduate School of Arts and Sciences at Harvard University. Postdoctoral fellows will be mentored by two HSPH faculty to support and encourage cross-disciplinary training. The Program proposes continued support for eight pre-doctoral students and seeks to add one postdoctoral fellow per year for a total of two each year of the award. These postdoctoral trainees will have an advanced degree (Ph.D., M.D., M.D./Ph.D. or other doctoral degree) relevant to exposure biology/environmental health sciences or computational areas of genomics/proteomics and will have specific interest in cross-training research experience. All trainees in the Interdisciplinary Training in Genes and Environment Program will be provided an outstanding opportunity to become equally skilled in genomics, environmental health sciences, and quantitative methods in order to attain leadership roles in interdisciplinary studies of human genes and the environment, with the ultimate goal of serving public health interests in developing effective disease prevention and intervention strategies.

Public Health Relevance

The Training in Genes and the Environment Program trains true collaborative partners able to pursue methodological research that is motivated by, and helps to solve, difficult analytic issues that arise in studies of human environmental exposures and genetic susceptibility to complex diseases. It also encourages interdisciplinary research, especially in genetics and the various 'omics' arising from new methodologies for characterizing biological activity associated with environmental exposures in laboratory and population sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
3T32ES016645-08S1
Application #
9390314
Study Section
Special Emphasis Panel (EHS (T1)S)
Program Officer
Shreffler, Carol A
Project Start
2008-07-01
Project End
2019-06-30
Budget Start
2017-02-01
Budget End
2017-06-30
Support Year
8
Fiscal Year
2017
Total Cost
$3,072
Indirect Cost
$228
Name
Harvard University
Department
Genetics
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
McCarthy, Ryan C; Sosa, Jose Carlo; Gardeck, Andrew M et al. (2018) Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem 293:7853-7863
Langston, P Kent; Shibata, Munehiko; Horng, Tiffany (2017) Metabolism Supports Macrophage Activation. Front Immunol 8:61
Lee, Lang Ho; Andraski, Allison B; Pieper, Brett et al. (2017) Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins. Proteomics 17:
Charles, Khanichi N; Li, Min-Dian; Engin, Feyza et al. (2017) Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep 21:393-402
Valvezan, Alexander J; Turner, Marc; Belaid, Amine et al. (2017) mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell 32:624-638.e5
MacArthur, Michael R; Mitchell, James R (2017) Feeding the Genome: In Silico Optimization of Dietary Amino Acid Composition. Cell Metab 25:486-488
Ilagan, Erika; Manning, Brendan D (2016) Emerging role of mTOR in the response to cancer therapeutics. Trends Cancer 2:241-251
Mendivil, Carlos O; Furtado, Jeremy; Morton, Allyson M et al. (2016) Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans. Arterioscler Thromb Vasc Biol 36:156-65
Knudsen, Nelson H; Lee, Chih-Hao (2016) Identity Crisis: CD301b(+) Mononuclear Phagocytes Blur the M1-M2 Macrophage Line. Immunity 45:461-463
McCarthy, Ryan C; Lu, Dah-Yuu; Alkhateeb, Ahmed et al. (2016) Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J Neuroinflammation 13:21

Showing the most recent 10 out of 65 publications