Abstract

This proposal is a request to continue to train predoctoral students at the Casey Eye Institute/Oregon Health Sciences University through the Ophthalmology/Immunology Training Grant. Funding for seven students is requested for the first year of renewal. Talented graduate students will continue to be selected from the departments of Cell Biology and Development, Molecular Microbiology and Immunology, Molecular Biology and Biochemistry, Neurosciences, or Physiology/Pharmacology. Graduate students will NOT be committed to careers in ophthalmic science but will receive a weekly exposure to research-opportunities in ophthalmology through a required course, Research Topics in Ophthalmology. Graduate students will be monitored closely and will be supervised by one of 18 experienced mentors. These preceptors were selected based on research quality, research funding, experience with graduate education, and expertise in a field such as immunology or molecular biology which can readily be extrapolated to ophthalmology. Funding of this proposal should help recruit outstanding predoctoral students into ophthalmic science.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
5T32EY007123-10
Application #
6178955
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Program Officer
Hunter, Chyren
Project Start
1991-09-30
Project End
2001-09-29
Budget Start
2000-09-30
Budget End
2001-09-29
Support Year
10
Fiscal Year
2000
Total Cost
$63,195
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Thauland, Timothy J; Koguchi, Yoshinobu; Wetzel, Scott A et al. (2008) Th1 and Th2 cells form morphologically distinct immunological synapses. J Immunol 181:393-9
Lang, Anna; Brien, James D; Messaoudi, Ilhem et al. (2008) Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication. J Immunol 180:4848-57
Kelly, Sean M; Vanslyke, Judy K; Musil, Linda S (2007) Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress. Mol Biol Cell 18:4279-91
Rosenzweig, Holly L; Minami, Manabu; Lessov, Nikola S et al. (2007) Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance. J Cereb Blood Flow Metab 27:1663-74
Davey, Michael P; Martin, Tammy M; Planck, Stephen R et al. (2006) Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc Res 71:103-7
Silverman, Matthew D; Babra, Bobby; Pan, Yuzhen et al. (2005) Differential E-selectin expression by iris versus retina microvascular endothelial cells cultured from the same individuals. Microvasc Res 70:32-42
Gaston, Isabelle; Johnson, Kara J; Oda, Tsukasa et al. (2004) Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl. Exp Hematol 32:113-21
Rosenzweig, Holly L; Lessov, Nikola S; Henshall, David C et al. (2004) Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke 35:2576-81
Janz, Jay M; Farrens, David L (2004) Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus. J Biol Chem 279:29767-73
Janz, Jay M; Farrens, David L (2004) Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis. J Biol Chem 279:55886-94

Showing the most recent 10 out of 27 publications