This application seeks five years' continued funding for a training program supporting four predoctoral students and one postdoctoral student with the aim of producing independent investigators capable of sustaining productive research programs in the vision sciences. The program is designed for training students in the areas of molecular/cellular biology, genetics, biochemistry, and immunology with particular focus on training in vision research. Preceptors have been selected with an emphasis both on the productivity of their current research and on their training records. The training program is organized to rigorously instruct and reinforce skills pertinent to experimental science and involves a combination of coursework, independent research, oral presentations (in-house, national and international), written research proposals, and the sharpening of communicative skills through continuous mentor feedback and peer review. The program is interdisciplinary and utilizes a core group of fourteen preceptors with active research and training programs whose primary and joint appointments span six basic science departments at the University of Florida College of Medicine. All predoctoral students are admitted through a common College-wide graduate training program, the Interdisciplinary Program in Biomedical Sciences (IDP), and follow a common first year core curriculum. The Department of Ophthalmology serves as the administrative and logistical center for the NEI training program, but individual faculty preceptors maintain primary graduate training appointments in the Departments of Cell Biology, Biochemistry, Molecular Genetics, Neuroscience, Pharmacology, and Physiology. The Department of Ophthalmology adds depth to the program by providing exposure to current problems in clinical ophthalmology in order to acquaint the graduate and postdoctoral student with relevant clinical issues in vision. Overall we propose an integrated program of research training in key biological disciplines aimed at producing productive vision researchers. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
2T32EY007132-13
Application #
6895025
Study Section
Special Emphasis Panel (ZEY1-VSN (04))
Program Officer
Hunter, Chyren
Project Start
1991-09-30
Project End
2009-09-29
Budget Start
2004-09-30
Budget End
2005-09-29
Support Year
13
Fiscal Year
2004
Total Cost
$197,778
Indirect Cost
Name
University of Florida
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Hooper, Marcus J; Wang, Jiangang; Browning, Robert et al. (2018) Damage-associated molecular pattern recognition is required for induction of retinal neuroprotective pathways in a sex-dependent manner. Sci Rep 8:9115
McCullough, K Tyler; Boye, Sanford L; Fajardo, Diego et al. (2018) Somatic gene editing of GUCY2D by AAV-CRISPR/Cas9 alters retinal structure and function in mouse and macaque. Hum Gene Ther :
Dinculescu, Astra; Dyka, Frank M; Min, Seok-Hong et al. (2018) Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epithelium. Adv Exp Med Biol 1074:61-66
Hooper, Marcus J; Ash, John D (2018) Müller Cell Biological Processes Associated with Leukemia Inhibitory Factor Expression. Adv Exp Med Biol 1074:479-484
Santiago, Clayton P; Keuthan, Casey J; Boye, Sanford L et al. (2018) A Drug-Tunable Gene Therapy for Broad-Spectrum Protection against Retinal Degeneration. Mol Ther 26:2407-2417
Choudhury, Shreyasi; Strang, Christianne E; Alexander, John J et al. (2016) Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells. Front Neurosci 10:551
Dinculescu, Astra; Stupay, Rachel M; Deng, Wen-Tao et al. (2016) AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy. PLoS One 11:e0148874
Boye, Sanford L; Bennett, Antonette; Scalabrino, Miranda L et al. (2016) Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors. J Virol 90:4215-4231
Dinculescu, Astra; Min, Seok-Hong; Dyka, Frank M et al. (2015) Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci 56:6971-80
Scalabrino, Miranda L; Boye, Sanford L; Fransen, Kathryn M H et al. (2015) Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. Hum Mol Genet 24:6229-39

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