In this renewal application, funding is requesed for continued support of the Johns Hopkins University T32-supported Visual Sciences Training Program (VSTP) (2020-2025). The VSTP is a combined effort of the Wilmer Eye Institute (Department of Ophthalmology) and the Departments of Neuroscience, Molecular Biology and Genetics, Biology, and Institute of Genetic Medicine. The program, administered and directed by PI Donald Zack and co-directors Jeremy Nathans and Amer Riazuddin, provides a multidisciplinary training platform with a diverse faculty covering cover many of the major avenues of modern visual science. The goal of the program is to recruit young, talented scientists into the visual sciences, and to provide them with broad theoretical and methodological research training, which will allow them to contribute to our understanding of the biology of vision and the pathological mechanisms responsible for visual loss in the context of human disease. Johns Hopkins is fortunate to have a large number of investigators exploring different avenues of vision research; their approaches range from the molecular and cellular to the systems levels, and the technologies they employ include cell biology, molecular biology, biochemistry, developmental neurobiology, stem cell biology, electrophysiology, functional imaging, psychophysics, bioinformatics, genomics, and genetics. This diverse vision research community provides a wide variety of research options for VSTP trainees. In this VSTP renewal application, we are proposing to accept two predoctoral students per year and support both of them for two years, and to accept two postdoctoral fellows per year, and to support each of them for one year. As part of our training program, the VSTP, in collaboration with Wilmer Eye Institute and other Hopkins graduate programs, organizes and provides vision-related courses, seminars, and related activities. Additional training in the problems of clinical ophthalmology, with an emphasis on translational problem solving, is available to all VSTP trainees through the medical student ophthalmology program and grand rounds. Through these programs, we hope to continue and expand upon the VSTP?s success in recruiting, inspiring, and training the next generation of vision scientists.

Public Health Relevance

The overall goal of the T32-supported Visual Sciences Training Program (VSTP) is to recruit talented young researchers, both pre- and postdoctoral fellows, and provide them with broad research training in the visual system, ranging from normal development and function to mechanisms of vision loss in the context of human disease. This training will prepare the trainees for careers in the visual sciences.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
2T32EY007143-26
Application #
9936784
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Agarwal, Neeraj
Project Start
1995-01-01
Project End
2025-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
26
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Schossig, Anna; Bloch-Zupan, Agnès; Lussi, Adrian et al. (2017) SLC13A5 is the second gene associated with Kohlschütter-Tönz syndrome. J Med Genet 54:54-62
White, David T; Sengupta, Sumitra; Saxena, Meera T et al. (2017) Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina. Proc Natl Acad Sci U S A 114:E3719-E3728
Wahlin, Karl J; Maruotti, Julien A; Sripathi, Srinivasa R et al. (2017) Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep 7:766
Foster, James W; Wahlin, Karl; Adams, Sheila M et al. (2017) Cornea organoids from human induced pluripotent stem cells. Sci Rep 7:41286
Florwick, Alyssa; Dharmaraj, Tejas; Jurgens, Julie et al. (2017) LMNA Sequences of 60,706 Unrelated Individuals Reveal 132 Novel Missense Variants in A-Type Lamins and Suggest a Link between Variant p.G602S and Type 2 Diabetes. Front Genet 8:79
Welsbie, Derek S; Mitchell, Katherine L; Jaskula-Ranga, Vinod et al. (2017) Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron 94:1142-1154.e6
Levin, Leonard A; Miller, Joan W; Zack, Donald J et al. (2017) Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. Ophthalmology 124:926-934
Barry, Michael P; Dagnelie, Gislin (2016) Hand-Camera Coordination Varies over Time in Users of the Argus(®) II Retinal Prosthesis System. Front Syst Neurosci 10:41
Gmeindl, Leon; Chiu, Yu-Chin; Esterman, Michael S et al. (2016) Tracking the will to attend: Cortical activity indexes self-generated, voluntary shifts of attention. Atten Percept Psychophys 78:2176-84
Barry, Michael P; Bittner, Ava K; Yang, Liancheng et al. (2016) Variability and Errors of Manually Digitized Goldmann Visual Fields. Optom Vis Sci 93:720-30

Showing the most recent 10 out of 66 publications