A comprehensive program has been designed with the purpose of training pre-and postdoctoral scientists in the broad area of vision science who are participating in graduate and postdoctoral programs in Neuroscience, Developmental Biology, Molecular Cell Biology, Molecular Genetics, Biochemistry, and Molecular Biophysics. The training program will be delivered by 29 preceptors, 23 of whom are NEI funded, studying nearly all aspects of ocular function and pathology. Predoctoral trainees will take courses that provide detailed information about the neurobiology of the visual system or a compretiensive course in all aspects of the development, physiology and pathology of the eye. Postdoctoral trainees are also encouraged to attend these courses. Pre- and postdoctoral trainees will be strongly encouraged to participate in the rich environment of seminars, advanced courses, honorary lectures, journal clubs, and retreats offered in the Division of Biology and Biomedical Sciences at Washington University and in the NEI sponsored course, Fundamental Issues in Vision Research. Many of these opportunities involve the participation of both basic and clinical scientists, assuring that trainees will learn about both the origins and treatment of human ocular diseases. The training program will support two postdoctoral trainees for their first year at Washington University. This will provide adequate time for them to apply for individual research training grant support. The predoctoral training program will support 6 graduate students. This will assure that an adequate number of vision science trainees will be available to enrich the training environment. The faculty members in the training program currently have 45 predoctoral and 59 postdoctoral trainees in their laboratories. This demonstrates the commitment of the faculty to training and illustrates the large size of the pool of applicants from which the training grant will draw. The overall goal of this program is to identify the most promising scientists and to provide them with a training environment that maximizes the probability that they will become productive contributors to the understanding and treatment of human ocular diseases.
| Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42 |
| Hughes, Andrew E O; Myers, Connie A; Corbo, Joseph C (2018) A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo. Genome Res 28:1520-1531 |
| Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902 |
| Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844 |
| Bassnett, Steven; Costello, M Joseph (2017) The cause and consequence of fiber cell compaction in the vertebrate lens. Exp Eye Res 156:50-57 |
| Vinberg, Frans; Wang, Tian; De Maria, Alicia et al. (2017) The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision. Elife 6: |
| Bassnett, Steven; Šiki?, Hrvoje (2017) The lens growth process. Prog Retin Eye Res 60:181-200 |
| Neimkin, Michael G; Custer, Philip L (2017) Compliance With Protective Lens Wear in Anophthalmic Patients. Ophthal Plast Reconstr Surg 33:61-64 |
| Ban, Norimitsu; Siegfried, Carla J; Lin, Jonathan B et al. (2017) GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight 2: |
| Shiels, Alan; Hejtmancik, J Fielding (2017) Mutations and mechanisms in congenital and age-related cataracts. Exp Eye Res 156:95-102 |
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