A wide-ranging program has been designed to train pre-and postdoctoral scientists in the broad area of vision science. Trainees participate in graduate and postdoctoral programs in Biochemistry, Computational & Molecular Biophysics, Computational & Systems Biology, Developmental, Regenerative & Stem Cell Biology, Human and Statistical Genetics, Immunology, Molecular Cell Biology, Molecular Genetics and Genomics, Molecular Microbiology & Microbial Pathogenesis, and Neurosciences. The training program will be delivered by 33 preceptors, 14 of whom are NEI funded, studying nearly all aspects of visual function and pathology. Predoctoral trainees will take courses that provide detailed information about the neurobiology of the visual system and/or a comprehensive course in all aspects of the development, physiology and pathology of the eye. Postdoctoral trainees are also encouraged to attend these courses. Pre- and postdoctoral trainees are strongly encouraged to participate in the rich environment of seminars, advanced courses, honorary lectures, journal clubs, and retreats offered in the Division of Biology and Biomedical Sciences at Washington University and in the NEI-sponsored course, Fundamental Issues in Vision Research. Many of these opportunities involve the participation of both basic and clinical scientists, assuring that trainees will learn about the origins and treatment of human ocular/visual system diseases. The training program supports two postdoctoral trainees for their first year at Washington University. This provides adequate time for them to apply for individual research training grant support. The predoctoral training program supports 6 graduate students. This assures that an adequate number of vision science trainees are available to enrich the training environment. The faculty members in the training program currently have 41 predoctoral and 37 postdoctoral trainees in their laboratories. This demonstrates the commitment of the faculty to training and illustrates the large size of the pool of applicants from which the trainin grant can draw. The overall goal of this program is to identify the most promising scientists and to provide them with a training environment that maximizes the probability that they will become productive contributors to the understanding and treatment of human ocular and visual system diseases.
Talented and well-trained scientists are essential for continued progress in vision research. The goal of this program is to select the best scientists from the large pool of graduate, MD/PhD candidates and postdoctoral fellows at Washington University and provide training that will prepare them to lead future research in vision.
| Ruzycki, Philip A; Zhang, Xiaodong; Chen, Shiming (2018) CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics Chromatin 11:42 |
| Hughes, Andrew E O; Myers, Connie A; Corbo, Joseph C (2018) A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo. Genome Res 28:1520-1531 |
| Brightman, Diana S; Grant, Rachel L; Ruzycki, Philip A et al. (2018) MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep 8:11902 |
| Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844 |
| Ban, Norimitsu; Siegfried, Carla J; Lin, Jonathan B et al. (2017) GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight 2: |
| Shiels, Alan; Hejtmancik, J Fielding (2017) Mutations and mechanisms in congenital and age-related cataracts. Exp Eye Res 156:95-102 |
| Ruzycki, Philip A; Linne, Courtney D; Hennig, Anne K et al. (2017) Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice. Invest Ophthalmol Vis Sci 58:4644-4653 |
| Hughes, Andrew E O; Enright, Jennifer M; Myers, Connie A et al. (2017) Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors. Sci Rep 7:43184 |
| Ferguson, Ian; Huecker, Julie; Huang, Jiayi et al. (2017) Risk factors for radiation-induced optic neuropathy: a case-control study. Clin Exp Ophthalmol 45:592-597 |
| Mitkus, Mindaugas; Olsson, Peter; Toomey, Matthew B et al. (2017) Specialized photoreceptor composition in the raptor fovea. J Comp Neurol 525:2152-2163 |
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