A mentor group composed of 13 senior and mid-level investigators, each with experience in research training and each with active and competitive research programs, propose to continue a relatively new research Training Program in Vision Science at the Medical College of Wisconsin (MOW) for another 5 years. The request is for 5 pre-doctoral trainees annually. The objective is to prepare trainees for research careers in ocular and vision research. This requires that students have a broad, multidisciplinary appreciation of the major features of the visual system, a contemporary understanding of the diseases that impact vision, and modern research skills and technologies for experimental work in the visual system. It also requires that trainees acquire the analytical and communication skills necessary to function in a multidisciplinary research environment. The mentor group provides experience in multiple facets of the visual system, ranging from fundamental photoreceptor biology and color vision to organization of the central vision within the brain. The mentors in the program also offer a wide range of state of the art technological know-how that includes molecular genetics, confocal and multiphoton imaging, adaptive optics, optical coherence tomography, functional magnetic resonance imaging, and electron spin resonance spectroscopy. Pre-doctoral trainees will complete a core curriculum of Molecular Genetics, Biochemistry, Cell Biology, and Neurobiology as well as required courses in """"""""Ethics and Integrity in Science"""""""" and """"""""The Biology of Vision"""""""" as a prelude to conducting dissertation research under the mentorship of a member of the program faculty. All trainees in mentor labs will also participate in a monthly Research Forum/Journal Club in Vision Science, a monthly Distinguished Lecture Series in Vision Science, and an annual Vision Science Colloquium. They will also attend and present papers at National meetings. Relevance: The goal of the project is to train a new generation of Vision Science researchers that are highly competent in the newest technologies and at the same time mindful of the important role of interdisciplinary and collaborative research in major scientific advances. Our challenge is to expose them to the major problems that need to be solved in vision research while providing in depth training in the technologies essential for research.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
5T32EY014537-09
Application #
8133842
Study Section
Special Emphasis Panel (ZEY1-VSN (06))
Program Officer
Agarwal, Neeraj
Project Start
2002-09-30
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
9
Fiscal Year
2011
Total Cost
$192,740
Indirect Cost
Name
Medical College of Wisconsin
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Huckenpahler, Alison; Wilk, Melissa; Link, Brian et al. (2018) Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina. Adv Exp Med Biol 1074:151-156
Lewis, Tylor R; Zareba, Mariusz; Link, Brian A et al. (2018) Cone myoid elongation involves unidirectional microtubule movement mediated by dynein-1. Mol Biol Cell 29:180-190
Sajdak, Benjamin S; Bell, Brent A; Lewis, Tylor R et al. (2018) Assessment of Outer Retinal Remodeling in the Hibernating 13-Lined Ground Squirrel. Invest Ophthalmol Vis Sci 59:2538-2547
Datta, Shyamtanu; Renwick, Marian; Chau, Viet Q et al. (2018) A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye - Implications for Ocular Gene Therapy. Invest Ophthalmol Vis Sci 59:4909-4920
Hendee, Kathryn E; Sorokina, Elena A; Muheisen, Sanaa S et al. (2018) PITX2 deficiency and associated human disease: insights from the zebrafish model. Hum Mol Genet 27:1675-1695
Reid, Christopher A; Nettesheim, Emily R; Connor, Thomas B et al. (2018) Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD. Sci Rep 8:11763
Zhang, Hanmeng; Mu, Lianwei; Wang, Dandan et al. (2018) Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain-derived neurotrophic factor. J Physiol 596:4511-4536
Lewis, Tylor R; Kundinger, Sean R; Link, Brian A et al. (2018) Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol 19:25
Lewis, Tylor R; Kundinger, Sean R; Pavlovich, Amira L et al. (2017) Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol 425:176-190
Hendee, Kathryn; Wang, Lauren Weiping; Reis, Linda M et al. (2017) Identification and functional analysis of an ADAMTSL1 variant associated with a complex phenotype including congenital glaucoma, craniofacial, and other systemic features in a three-generation human pedigree. Hum Mutat 38:1485-1490

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