A. Goals and Description. This program will provide integrated predoctoral training in the Pharmacological Sciences for 15 students in the Division of Cell and Molecular Biology (DCMB) of the University of Texas Southwestern Medical Center. After appropriate postdoctoral training, graduates will be well prepared to initiate independent research programs that emphasize molecular and cellular approaches to understanding the mechanisms of action of drugs, hormones, and other regulatory molecules. Students with strong undergraduate training in physical and biological sciences will receive interdisciplinary instruction in both molecular and physiological pharmacology, biochemistry, molecular and cell biology, and physiology. Advanced didactic training, student seminars, journal clubs, research rotations, and dissertation research projects will complete the training experience. The students also receive opportunities to present their work orally or in poster form at national and international meetings. B. Trainees. Students who have completed the integrated first year curriculum of the DCMB or within the first two years of training in our M.D./Ph.D. program will be considered for appointment to the program by the Steering Committee. Most students participate in the Cell Regulation Graduate Program of the DCMB. Selection will be based on the student's undergraduate and graduate school performance and on the commitment of the student and his or her mentor to pursue a course of training consistent with the goals and guidelines of the program. C. Faculty. The 49 individuals who comprise the training faculty come from seven different academic departments and represent eight interdisciplinary graduate training programs of the DCMB. These individuals have a wealth of experience and provide substantial diversity in their approaches to problems of pharmacological interest. In addition, a recently implemented Endowed Scholars Program continues to provide a yearly influx of talented new faculty to UTSW.
| Cozza, Giorgio; Moro, Enrico; Black, Miles et al. (2018) The Golgi 'casein kinase' Fam20C is a genuine 'phosvitin kinase' and phosphorylates polyserine stretches devoid of the canonical consensus. FEBS J 285:4674-4683 |
| Pendleton, Kathryn E; Park, Sung-Kyun; Hunter, Olga V et al. (2018) Balance between MAT2A intron detention and splicing is determined cotranscriptionally. RNA 24:778-786 |
| Meng, Delong; Frank, Anderson R; Jewell, Jenna L (2018) mTOR signaling in stem and progenitor cells. Development 145: |
| Doxtader, Katelyn A; Wang, Ping; Scarborough, Anna M et al. (2018) Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. Mol Cell 71:1001-1011.e4 |
| Doyle, Wayne I; Meeks, Julian P (2018) Excreted Steroids in Vertebrate Social Communication. J Neurosci 38:3377-3387 |
| Fan, Chen; Yarravarapu, Nageswari; Chen, Hua et al. (2018) Regulation of tankyrase activity by a catalytic domain dimer interface. Biochem Biophys Res Commun 503:1780-1785 |
| Gibbs, Zane A; Whitehurst, Angelique W (2018) Emerging Contributions of Cancer/Testis Antigens to Neoplastic Behaviors. Trends Cancer 4:701-712 |
| Pendleton, Kathryn E; Chen, Beibei; Liu, Kuanqing et al. (2017) The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell 169:824-835.e14 |
| Nguyen, Thu P; Frank, Anderson R; Jewell, Jenna L (2017) Amino acid and small GTPase regulation of mTORC1. Cell Logist 7:e1378794 |
| Elkin, Sarah R; Lakoduk, Ashley M; Schmid, Sandra L (2016) Endocytic pathways and endosomal trafficking: a primer. Wien Med Wochenschr 166:196-204 |
Showing the most recent 10 out of 178 publications
