The Genetics Training Program at UCLA is now entering its 29th year of activity. Its objectives are the recruitment genetics-oriented UCLA students into a defined program that enriches training, monitors progress, and prepares for postdoctoral work and beyond. Its rationale is based on the continuing need for research into fundamental genetic processes such as the mechanisms of gene regulation, genetic recombination and transfer, DMA damage and repair, epigenetics, the genetic basis of disease, and so forth. These areas often overlap the application of genetic technologies to other fields. The program's design is to identify faculty with research projects related to this rationale, identify and recruit like-minded students, and join these faculty and students into a program that emphasizes breadth in genetics training, teaching of genetic principles and methods, in depth research analysis of genetic mechanisms, and creation of the necessary talents for conveying their discoveries and conclusions in research publications and in professional seminars. All trainees are at the pre-PhD level. Requirements and oversight continue until degree. Of the 17 trainees now in the Program, 11 are supported by NIH and the balance by institutional or individual awards. Currently, 18% of our trainees are from under-represented minorities. We request modest increases in the slots provided by NIH, whilst continuing institutional support. Trainees come to the Program at the beginning of their 2nd year, having completed the bulk of their coursework, some seminar obligations, but no TAships. All have rotated through 3 or more labs and have joined one. If appointed as trainees, they receive 3 years of full stipend and fees support (pending annual evaluation and reappointment), and must meet a series of Program requirements during that time (progress, specific TAing, seminars, etc.) or soon afterward. Time to degree averages 5.8 years for our trainees, a bit ahead of the average.

Public Health Relevance

The work being accomplished by our trainees and their mentors is highly relevant to public health. Some are working on the agents of infectious diseases, including viruses and the bacterium that causes Anthrax. Others are working on important diseases that have a genetic basis, including heart disease and attention deficit disorder. Others work on some of the most fundamental of genetic process, all of which underlie diseases at one level or another.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007104-34S1
Application #
8282232
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1975-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
34
Fiscal Year
2011
Total Cost
$114,126
Indirect Cost
Name
University of California Los Angeles
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Daboussi, Lydia; Costaguta, Giancarlo; Ghukasyan, Razmik et al. (2017) Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network. Proc Natl Acad Sci U S A 114:3433-3438
Hartenstein, Volker; Cruz, Louie; Lovick, Jennifer K et al. (2017) Developmental analysis of the dopamine-containing neurons of the Drosophila brain. J Comp Neurol 525:363-379
Gibbs, Elizabeth M; Marshall, Jamie L; Ma, Eva et al. (2016) High levels of sarcospan are well tolerated and act as a sarcolemmal stabilizer to address skeletal muscle and pulmonary dysfunction in DMD. Hum Mol Genet 25:5395-5406
Lovick, Jennifer K; Kong, Angel; Omoto, Jaison J et al. (2016) Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain. Dev Neurobiol 76:434-51
Shimogawa, Michelle M; Saada, Edwin A; Vashisht, Ajay A et al. (2015) Cell Surface Proteomics Provides Insight into Stage-Specific Remodeling of the Host-Parasite Interface in Trypanosoma brucei. Mol Cell Proteomics 14:1977-88
Cavanaugh, Ann M; Huang, Jie; Chen, Jau-Nian (2015) Two developmentally distinct populations of neural crest cells contribute to the zebrafish heart. Dev Biol 404:103-12
Saada, Edwin A; Kabututu, Z Pius; Lopez, Miguel et al. (2014) Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. Eukaryot Cell 13:1064-76
Chin, Randall M; Fu, Xudong; Pai, Melody Y et al. (2014) The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510:397-401
Shen, Qinfang; Yamano, Koji; Head, Brian P et al. (2014) Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol Biol Cell 25:145-59
Ghazalpour, Anatole; Bennett, Brian J; Shih, Diana et al. (2014) Genetic regulation of mouse liver metabolite levels. Mol Syst Biol 10:730

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