The goal of this proposal is to train predoctoral students broadly in the discipline of genetics. Graduate students admitted to the University of Wisconsin doctoral program in Genetics will be supported in the initial years of their graduate training. The Genetics doctoral program presently consists of 73 faculty representing 20 different departments in the biological sciences and 65 students studying with 33 different faculty trainers. The collective research interests of program faculty and students encompass virtually the entire breadth and depth of contemporary genetics. Trainees are selected based on prior academic achievements, research experience, and personal interviews conducted before acceptance into the program. Accepted students identify Genetics as their primary academic pursuit and choose thesis advisors based on their individual research interests. The Genetics doctoral program is a campus-wide training program administered by the Laboratory of Genetics, which is housed in two adjacent modern research buildings. Supported students complete a rigorous academic program consisting of both formal coursework and individualized mentoring in genetics;Formal coursework includes a core curriculum of required genetics courses, specialized electives identified by students together with their Thesis Advisory Committee, and a course in the ethical conduct of science. Students gain teaching and communication experience by (i) serving for one semester as a Teaching Assistant for an undergraduate Genetics course and (ii) presenting their thesis research in formal settings before faculty and students of the program. Student performance is evaluated by a two-part qualifying examination that tests their understanding of broad genetic principles and their ability to propose, accomplish, and defend a thesis research project. Student progress is monitored annually by a Thesis Advisory Committee. The Genetics Training Grant develops young investigators as independent scientists by providing a rigorous and broad education in the science of genetics. Our graduates bring the methods and logic of genetic analysis to bear on contemporary research problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007133-36
Application #
7880712
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1975-07-01
Project End
2014-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
36
Fiscal Year
2010
Total Cost
$704,181
Indirect Cost
Name
University of Wisconsin Madison
Department
Genetics
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Krause, David J; Kominek, Jacek; Opulente, Dana A et al. (2018) Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts. Proc Natl Acad Sci U S A 115:11030-11035
Rytz, Thérèse C; Miller, Marcus J; McLoughlin, Fionn et al. (2018) SUMOylome Profiling Reveals a Diverse Array of Nuclear Targets Modified by the SUMO Ligase SIZ1 during Heat Stress. Plant Cell 30:1077-1099
Muir, Virginia S; Gasch, Audrey P; Anderson, Philip (2018) The Substrates of Nonsense-Mediated mRNA Decay in Caenorhabditis elegans. G3 (Bethesda) 8:195-205
Schwahn, Denise J; Wang, Richard J; White, Michael A et al. (2018) Genetic Dissection of Hybrid Male Sterility Across Stages of Spermatogenesis. Genetics 210:1453-1465
Hvala, John A; Frayer, Megan E; Payseur, Bret A (2018) Signatures of hybridization and speciation in genomic patterns of ancestry. Evolution :
Nantie, Leah B; Young, Randee E; Paltzer, Wyatt G et al. (2018) Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing. Development 145:
Pfannenstiel, Brandon T; Greco, Claudio; Sukowaty, Andrew T et al. (2018) The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus. Fungal Genet Biol 120:9-18
Pleiman, Jennifer K; Irving, Amy A; Wang, Zhishi et al. (2018) The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PLoS Genet 14:e1007611
Lind, Abigail L; Lim, Fang Yun; Soukup, Alexandra A et al. (2018) An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus. mSphere 3:
Parmenter, Michelle D; Nelson, Jacob P; Weigel, Sara E et al. (2018) Masticatory Apparatus Performance and Functional Morphology in the Extremely Large Mice from Gough Island. Anat Rec (Hoboken) :

Showing the most recent 10 out of 281 publications