Abstract

The Molecular and Cellular Biology (MCB) training program at The University of Chicago is a long-standing interdisciplinary program that trains graduate students for independent academic and research careers in the biomedical sciences. This application requests support for years 33 through 37. The mission of the MCB program is to train students to analyze biological processes using the conceptual and experimental tools of biochemistry and molecular, cellular, and structural biology. This training program is focused around a coherent set of scientific themes, but is intrinsically interdisciplinary in nature. The students take a core group of courses in molecular biology, cellular biology, and macromolecular structure. They subsequently pursue research projects involving a diverse set of model systems and approaches. The scientific interactions among the trainees are extensive, and are promoted by formal mechanisms that include the MCB Research in Progress series and the MCB mini-symposium, as well as the MCB-affiliated Graduate Student Seminar series and Molecular Biosciences retreat. The MCB Director or co-Director meets individually with trainees on an annual basis in order to monitor their academic and research progress. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007183-32A1
Application #
7237575
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (CG))
Program Officer
Preusch, Peter C
Project Start
1975-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
32
Fiscal Year
2007
Total Cost
$1,255,519
Indirect Cost

  Institution

Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Kudryashova, Elena; Heisler, David B; Williams, Blake et al. (2018) Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins. Curr Biol 28:1536-1547.e9
Steimle, Jeffrey D; Rankin, Scott A; Slagle, Christopher E et al. (2018) Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A 115:E10615-E10624
Kerr, Daniel; Tietjen, Gregory T; Gong, Zhiliang et al. (2018) Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins. Biochim Biophys Acta Biomembr 1860:2126-2133
Briscoe, Steven D; Ragsdale, Clifton W (2018) Molecular anatomy of the alligator dorsal telencephalon. J Comp Neurol 526:1613-1646
Xu, Jiajie; Vanderzalm, Pamela J; Ludwig, Michael et al. (2018) Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Dev Cell 46:271-284.e5
Day, Kasey J; Casler, Jason C; Glick, Benjamin S (2018) Budding Yeast Has a Minimal Endomembrane System. Dev Cell 44:56-72.e4
Sanchez, Jacint G; Sparrer, Konstantin M J; Chiang, Cindy et al. (2018) TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. J Mol Biol 430:5280-5293
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Han, Julianna; Perez, Jasmine T; Chen, Cindy et al. (2018) Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication. Cell Rep 23:596-607
Li, Jingxian; Shalev-Benami, Moran; Sando, Richard et al. (2018) Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell 173:735-748.e15

Showing the most recent 10 out of 316 publications