The Cell and Molecular Genetics (CMG) Training Program at the University of California, San Diego is currently in its 38th year. This program is a cornerstone of the PhD program in the biological sciences at UCSD, as it trains the best graduate students from the Biological Sciences/Salk and Chemistry/Biochemistry PhD programs. The CMG Training Program mission is to provide rigorous training for PhD students interested in the molecular mechanisms of a diverse array of biological phenomena. Specific emphasis is placed upon the creativity, quality, and impact of the research, the ethical conduct of research, the achievement of racial diversity among researchers, the ability of the trainees to communicate their results effectively, and the promotion of cooperation and collaboration among scientists. The CMG Program Director is Dr. Randolph Hampton, Professor of Biological Sciences since 1995. Dr. Hampton works closely with Executive Director Dr. Amy Pasquinelli, and the CMG Advisory Committee that consists of Drs. Deborah Yelon, James Kadonaga, Lorraine Pillus, Partho Ghosh, Gentry Patrick, Reuben Shaw, Roy Wollman, and Scott Rifkin. There are currently 114 training faculty, most of them from the UCSD Division of Biological Sciences, the Salk Institute, and the UCSD Department of Chemistry and Biochemistry. The CMG Training Program provides training for 33 outstanding Ph.D. students during years 2 and 3 of their training. Trainees are selected from a current pool of about 220 qualified students that are part of the PhD degree/entry programs in the UCSD Division of Biological Sciences and the UCSD Department of Chemistry and Biochemistry. The trainees fulfill the general requirements of their respective degree/entry programs, and additionally participate in CMG- specific activities, which include a class called Advances in Cellular and Molecular Mechanisms, a biannual CMG Trainee Research Colloquium, choosing and hosting CMG-Invited Biology Division Seminar speakers, an annual White Board Jam (to hone non-digital exposition), the annual One Book, One Program reading and discussion of a science-related book, an IDP workshop, a Path-to-Career workshop, and annual One-on-One Conferences with the Program Director. Over the past 10 years, more than 100 CMG trainees have successfully completed their Ph.D. theses, contributing an enormous wealth of important knowledge in nearly 500 publications. The Biological Sciences continues to grow dramatically, and we envision the implementation of an ever stronger CMG Training Program over the next five years.

Public Health Relevance

The CMG Program trains a select group of graduate students in the molecular mechanisms of diverse biological phenomena. These phenomena include aging, wound healing, nerve regeneration, resistance to infectious disease, cancer, drought stress in plants, biofuel strategies, and many others. This training program generates the scientific talent base that is required for informed improvements in human health and society.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007240-43
Application #
9748525
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Salazar, Desiree Lynn
Project Start
1975-07-01
Project End
2020-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
43
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Loureiro, María Eugenia; Zorzetto-Fernandes, Andre Luiz; Radoshitzky, Sheli et al. (2018) DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog 14:e1007125
Piña, Francisco; Yagisawa, Fumi; Obara, Keisuke et al. (2018) Sphingolipids activate the endoplasmic reticulum stress surveillance pathway. J Cell Biol 217:495-505
E, Lezi; Zhou, Ting; Koh, Sehwon et al. (2018) An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron 97:125-138.e5
Lubin, Johnathan W; Tucey, Timothy M; Lundblad, Victoria (2018) Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo. Genetics 208:97-110
Morin, Manon; Pierce, Emily C; Dutton, Rachel J (2018) Changes in the genetic requirements for microbial interactions with increasing community complexity. Elife 7:
Rubin, Benjamin E; Huynh, TuAnh Ngoc; Welkie, David G et al. (2018) High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival. PLoS Genet 14:e1007301
Glustrom, Leslie W; Lyon, Kenneth R; Paschini, Margherita et al. (2018) Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. Proc Natl Acad Sci U S A 115:10315-10320
Liu, Wanlu; Duttke, Sascha H; Hetzel, Jonathan et al. (2018) RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. Nat Plants 4:181-188
Rahnamoun, Homa; Hong, Juyeong; Sun, Zhengxi et al. (2018) Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. J Biol Chem 293:13234-13246
Hagstrom, Danielle; Truong, Lisa; Zhang, Siqi et al. (2018) Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci :

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